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Triazolium salts as inhibitors of PAR1, their preparation and use as a medicine
专利权人:
SANOFI
发明人:
HEINELT, Uwe,WEHNER, Volkmar,HERRMANN, Matthias,SCHOENAFINGER, Karl,STEINHAGEN, Henning
申请号:
ES09707892
公开号:
ES2553588T3
申请日:
2009.01.23
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
Compound of formula I, ** Formula ** and / or all stereoisomeric or tautomeric forms of the compound of formula I and / or mixtures of these forms in any relationship, wherein X represents C-R1 or N, A- represents an anion of an organic or inorganic acid, Q1 represents a hydrogen atom, -alkyl (C1-C6), -cycloalkyl (C3-C6), -alkylene (C0C4) -C (O) -O-R11, -alkylene (C0 -C4) -C (O) -N (R11) -R12, -alkylene (C0-C4) -C (O) -R11, -OH, -O-(C1-C6) alkyl or -O-cycloalkyl (C3 -C6), where alkyl and cycloalkyl are in each case unsubstituted or substituted once, twice or three times, independently from each other, with -C1-C4 alkyl, -C3-C6 alkyl, OH, - O (C1-C6) alkyl or -O-C3-C6 cycloalkyl, wherein in alkyl or cycloalkyl hydrogen atoms may be replaced, in whole or in part, by fluorine, Q2 and Q3 are the same or different and, independently of each other, represent a hydrogen atom, -C1-C6 alkyl or -C3-C6-cycloalkyl, wherein in alkyl or cycloalkyl hydrogen atoms may be replaced, in whole or in part, by fluorine, R1, R2, R3 and R4 are the same or different and, independently of each other, represent a hydrogen atom, - alkyl (C1-C6), -C3-C6 cycloalkyl, -O-C1-C8 alkyl, -O-C3-C6 cycloalkyl, -C0-C4 alkyl -C (O) -N (R11 ) -R12, - alkylene (C0-C4) -C (O) -O-R11, -alkylene (C0-C4) -N (R11) -C (O) -O-R12, -alkylene (C0-C4) -C (O) -R11, -alkylene (C0-C4) - N (R11) -R12, -alkylene (C0-C4) -N (R11) -C (O) -R12, halogen, OH, -CN, -NO2, -SO2CH3, -Si [-C1-C4 alkyl] 3, -C1-C6 alkyl-O-C1-C6 alkyl, -O-C1-C6 alkyl-O-alkyl C1-C6), -O-alkylene (C0-C4) -aryl (C6-C14), -O-alkylene (C1-C4) -cycloalkyl (C3-C6), -Het (C4-C15) or -O- alkylene (C1-C6) -O-alkylene (C1-C6) -O-alkyl (C1-C6), wherein alkyl, alkylene and cycloalkyl are in each case unsubstituted or substituted once, twice or three times, independently one on the other, by -alkyl (C1-C4), -cycloalkyl (C3-C6) yl, OH, -O-(C1-C6) alkyl or -O-cycloalkyl (C3-C6), wherein in alkyl, alkylene or cycloalkyl hydrogen atoms may be replaced, in whole or in p
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