BUSCH, BRETT B.,FLATT, BRENTON T.,GU, XIAO-HUI,LU, SHAO-PO,MARTIN, RICHARD,MOHAN, RAJU,NYMAN, MICHAEL CHARLES,SCHWEIGER, EDWIN,STEVENS, WILLIAM C.,WANG, TIE-LIN,XIE, YINONG
申请号：
ES06785562
公开号：
ES2525217T3
申请日:
2006.06.26
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound according to one of the following formulas: ** Formula ** or a pharmaceutically acceptable salt thereof, where R1 is -L1-R5, where L1 is a bond, - [C (R15) 2] m- or -C3- C8cycloalkyl-, where each R15 is independently hydrogen, halogen, (C1-C6) alkyl, (C3-C6) cycloalkyl or (C1-C6) haloalkyl, and R5 is phenyl or pyridyl, each optionally substituted with one or two R5a, where each R5a is independently -halogen, -C1-C6alkoxy, -C1-C6alkyl or -C1-C6haloalkyl； R2 and R21 are each independently -H, - [C (R15) 2] m-OH, -C1-C6alkyl, -C1-C6haloalkyl, halogen, -C (O) N (R11) 2 or -COOR11； with the proviso that R2 and R21 are not simultaneously hydrogen； G is a group of formula ** Formula ** where J is phenyl, pyridyl or thienyl； K is phenyl or pyridyl； L2 is a link； each R41 is -halogen, -C1-C6alkyl or C1-C6haloalkyl, and each R4 is -halogen, - [C (R15) 2] m-OH, -SO2R11, -SO2N (R11) 2, -C (O) N (R11) 2, -COOR11, -C1-C6alkyl or -C1-C6haloalkyl； each m is 0, 1, 2, 3, 4, 5 or 6； q is 0, 1, 2, 3, 4 or 5, with the proviso that q is 0 if, and only if, K is not phenyl； and q 'is 0, 1, 2, 3 or 4； Each R11 is independently -hydrogen, -C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C8cycloalkyl, (C3- C8cycloalkyl) -C1-C6alkyl-, (C3-C8cycloalkenyl) -C1-C6alkyl- (C ) -C2-C6alkenyl-, -C1-C6haloalkyl, -N (R12) 2, aryl, - (C1-C6) alkylaryl, heteroaryl, - (C1-C6) alkylheteroaryl, heterocyclyl or - (C1-C6) alkylheterocyclyl, where any of the R11 is optionally substituted with one or more R12 radicals； Each R12 is independently halogen, C1-C6haloalkyl, C1-C6alkyl, C1-C6alkoxy, (C0-C6alkyl) C>； = O (OR13), C0- C6alkylOR13, C0-C6alkylCOR13, C0-C6alkylSO2R13, C0-C6alkylCON (R13 , C0-C6alkylCONR13OR13, C0- C6alkylSO2N (R13) 2, C0-C6alkylSR13, C0-C6haloalkylOR13, aryloxy, aralkyloxy, aryloxyalkyl, C0-6alkoxyaryl, arylC0-6alkylcarboxi, -C0-C13-R0 -13-R0-C13-R0-C13-R0-C13-R0-C13-R0-C13-R0-C13-R0-C13-R -13- R0-C13-R -13- R0-C13-R0-C13-R -13-R02 6 alkylCOOR13； and each R13 is independently hydro
