Yong Zhang,Ivar M. McDonald,Naidu S. Chowdari,Tram N. Huynh,Robert M. Borzilleri,Sanjeev Gangwar
申请号:
US14994296
公开号:
US09527871B2
申请日:
2016.01.13
申请国别(地区):
US
年份:
2016
代理人:
摘要:
Benzodiazepine dimers having a structure represented bywherein R1 iswherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).