Yong ZHANG,Robert M. BORZILLERI,Andrew J. TEBBEN,Erik M. STANG,Andrew F. DONNELL,Gretchen M. SCHROEDER,Heidi L. PEREZ,Donna D. WEI
申请号：
US15189388
公开号：
US20160376288A1
申请日:
2016.06.22
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Macrocyclic benzodiazepine dimers having a structure represented by formula Iwhere A and B are independently according to formulae Ia or Iband the other variables in formulae I, Ia, and Ib are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used as the drug component in an antibody-drug conjugate (ADC).
