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MACROCYCLIC BENZODIAZEPINE DIMERS CONJUGATES THEREOF PREPARATION AND USES
专利权人:
发明人:
ZHANG YONG,BORZILLERI ROBERT M,TEBBEN ANDREW J,STANG ERIK M,DONNELL ANDREW F,SCHROEDER GRETCHEN M,PEREZ HEIDI L,WEI DONNA D
申请号:
IN201817002317
公开号:
IN201817002317A
申请日:
2018.01.19
申请国别(地区):
IN
年份:
2018
代理人:
摘要:
Macrocyclic benzodiazepine dimers having a structure represented by formula (I) where A and B are independently according to formulae (Ia) or (Ib) and the other variables in formulae (I) (Ia) and (Ib) are as defined in the application. Such dimers are useful as anti cancer agents especially when used as the drug component in an antibody drug conjugate (ADC).
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