GUND VITTHAL GENBHAU,KULKARNI PRASAD RAMAKANT,SRIVASTAVA NEETA,BHOSALE SHYAM MAHARU
申请号：
IN3726/MUM/2012
公开号：
IN2012MU03726A
申请日:
2012.12.31
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
The present invention relates to an improved process for the preparation of Nicorandil of Formula I, having HPLC purity of more that 99.7% comprising condensation of methyl nicotinate with ethanolamine and isolating the compound of Formula II nitrating the N-(2-hydroxyethyl) nicotinamide of Formula II with 70% nitric acid in presence of acetic anhydride and isolating the Nicorandil nitrate salt of Formula III dissolving the Nicorandil nitrate salt of Formula III in water, charcoalizing thus formed solution and adjusting the pH of the solution with a weak base to obtain crude Nicorandil having HPLC purity of more than 99% dissolving the crude Nicorandil in an alcohol and recrystallizing by addition of water to obtain crystals of Nicorandil having HPLC purity of more than 99.7%
