SELS MALEATES DE (E)-N-{4-[3-CHLORO-4-(2-PYRIDINYLMETHOXY)ANILINO]-3-CYANO-7-ETHOXY-6-QUINOLINYL}-4-(DIMETHYLAMINO)-2-BUTENAMIDE ET LEURS FORMES CRISTALLINES

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专利权人:

WYETH LLC

发明人:

LU, QINGHONG,KU, MANNCHING SHERRY,CHEW, WARREN,CHEAL, GLORIA K.,HADFIELD, ANTHONY F.,MIRMEHRABI, MAHMOUD

申请号：

CA2928071

公开号：

CA2928071C

申请日:

2008.10.16

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro -4-(2-hyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4- (dimethylamino) -2-butenamide, (NERATINIB) methods of preparing crystalline maleate salt forms, the associated compounds, such as its degradation and impurities and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.

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