Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl} -4-(dimethylamino)-2-butenamide and crystalline forms thereof

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专利权人:

Wyeth LLC

发明人:

Lu, Qinghong,Ku, Mannching Sherry,Chew, Warren,Cheal, Gloria K.,Hadfield, Anthony F.,Mirmehrabi, Mahmoud

申请号：

AU2013203571

公开号：

AU2013203571A1

申请日:

2013.04.10

申请国别(地区):

AU

年份:

2013

代理人:

摘要：

#$%^&*AU2013203571A120130502.pdf#####ABSTRACT The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(2pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2butenamide, (NERATINIB) methods of preparing crystalline maleate salt forms, the 5 associated compounds, such as its degradation and impurities and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.

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