Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl} -4-(dimethylamino)-2-butenamide and crystalline forms thereof

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专利权人:

Wyeth LLC

发明人:

Lu, Qinghong,Hadfield, Anthony F.,Ku, Mannching Sherry,Cheal, Gloria K.,Chew, Warren,Mirmehrabi, Mahmoud

申请号：

AU2008312474

公开号：

AU2008312474B2

申请日:

2008.10.16

申请国别(地区):

AU

年份:

2014

代理人:

摘要：

The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide,(NERATINIB) methods of preparing crystalline maleate salt forms, the associatedcompounds, such as its degradation and impurities and pharmaceutical compositionscontaining the same. The maleate salts are useful in treating cancers, particularlythose affected by kinases of the epidermal growth factor receptor family.

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