Maleate salts of (e)-n-{ 4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl} -4-(dimethylamino)-2-butenamide and crystalline forms thereof

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专利权人:

WYETH LLC

发明人:

LU QINGHONG,KU MANNCHING SHERRY,CHEW WARREN,CHEAL GLORIA K.,HADFIELD ANTHONY F.,MIRMEHRABI MAHMOUD

申请号：

NZ61613608

公开号：

NZ616136A

申请日:

2008.10.16

申请国别(地区):

NZ

年份:

2015

代理人:

摘要：

Disclosed herein are maleate salt forms of (E)-N-{ 4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl} -4-(dimethylamino)-2-butenamide, (NERATINIB) methods of preparing crystalline maleate salt forms, the associated compounds, such as its degradation and impurities and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.

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中国工程科技知识中心

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