Maleate salts of (e)-n-{ 4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl} -4-(dimethylamino)-2-butenamide and crystalline forms thereof
LU QINGHONG,KU MANNCHING SHERRY,CHEW WARREN,CHEAL GLORIA K.,HADFIELD ANTHONY F.,MIRMEHRABI MAHMOUD
申请号：
NZ70564108
公开号：
NZ705641A
申请日:
2008.10.16
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Disclosed herein are maleate salt forms of (E)-N-{ 4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl} -4-(dimethylamino)-2-butenamide, (NERATINIB) methods of preparing crystalline maleate salt forms such as a partially hydrate form, the associated compounds, such as its degradation and impurities and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.
