SELS MALEATES DE (E)-N-{4-[3-CHLORO-4-(2-PYRIDINYLMETHOXY)ANILINO]-3-CYANO-7-ETHOXY-6-QUINOLINYL}-4-(DIMETHYLAMINO)-2-BUTENAMIDE ET LEURS FORMES CRISTALLINES
LU, QINGHONG,KU, MANNCHING SHERRY,CHEW, WARREN,CHEAL, GLORIA K.,HADFIELD, ANTHONY F.,MIRMEHRABI, MAHMOUD
申请号：
CA2702930
公开号：
CA2702930C
申请日:
2008.10.16
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(3-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}4-(dimethylamino)-2-butenamide,(NERATINIB) methods of preparing crystalline maleate saltforms, the associated compounds, such as its degradation and impurities andpharmaceutical compositions containing the same. Themaleate salts are useful in treating cancers, particularly those affected bykinases of the epidermal growth factor receptor family.
