Heckel, Armin,Roth, Gerald Jürgen,Grauert, Matthias,Dahmann, Georg,Park, John Edward,Chaudhary, Nveed,Brandl, Trixi
申请号：
NO20161634
公开号：
NO341591B1
申请日:
2016.10.12
申请国别(地区):
NO
年份:
2017
代理人:
摘要：
Indolinona refers to compounds of formula I, where X is o or s； r1 is H or a prodrug is carboxy Group； R2, C1 - C6 carbonyl alkoxy, among others； R3 is C1 - C6 h, alkyl, cycloalkyl C3 - C7, among others； R4 is cycloalkyl C3 - C7； R6 h, F, cyano, amino, among others； R5 C1 - C3 is H, alkyl, Tre.Preferred compounds are: Z - 3 - [1 - (4 - (piperidin-1-yl - anilino methyl) phenyl) methylene] - 1 - 6 - 2 - indolinona Ethoxycarbonyl -, Z - [3 - (1 - (4 - (piperidin-1-yl - anilino methyl) phenyl) methylene] - 1 - 6 - 2 - carbamoyl - indolinona, among others. It also relates to a Pharmaceutical composition. These compounds are useful for the Treatment or prevention of fibrotic Diseases specificForeliggende oppfinnelse angår anvendelse av indolinoner med den generelle formel (I) substituert i 6-stillingen, hvor R1 til R5 og X er definert som i krav 1, isomerene og saltene derav, spesielt de fysiologisk akseptable salter derav, som et medikament for forebygging eller behandling av spesifikke fibrotiske sykdommer.
