HEIMBACH, DIRK,ROHRIG, SUSANNE,CANCHO GRANDE, YOLANDA,BENDER, ECKHARD,ZIMMERMANN, KATJA,BUCHMULLER, ANJA,GERDES, CHRISTOPH,GNOTH, MARK JEAN,GERICKE, KERSTEN MATTHIAS,JESKE, MARIO
申请号：
PE0020102011
公开号：
PE09342012A1
申请日:
2010.05.19
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Referring to a compound of formula I, where a is o, N, H alqulo NR4 R4 is C1, C3, among others r1 is phenyl or substituted by Halogen 1 - 3, monofluorometilo Difluoromethoxy, CF3, among others R2 is alkyl, cycloalkyl - C1 - C6 C3, C6, heterociclilo of 4 - 6 members, phenyl heteroaryl 5 - 6. Bros, among others R3 is c1-c6 alkyl, alkoxy alquilamino C1 - C6 C1 - C3 - C7 C6, cycloalkyl,Among others. Preferred compounds are: (3 - (3 - [cyclopropyl (methyl) amino] - 1,2,4 - Oxadiazoles - il - 5} - 5 - [4 - (trifluoromethyl) phenyl] (piperidin-1-yl) - 4 - (IL) methanone il - 4 - (3 - [{- 3 - (piperidin-1-yl) - 1,2,4 - Oxadiazoles - 5 - yl] - 5 - [4 - (trifluoromethyl) phenyl] piperidin-1-yl) methanone among others.These compounds are useful in the prophylaxis and \/ or treatment of cardiovascular disorders, Disorders tromboemboliticos and \/ OR tumorREFERIDA A UN COMPUESTOS DE FORMULA I, DONDE A ES O, N, NR4 R4 ES H, ALQULO C1-C3, ENTRE OTROS R1 ES FENILO SUSTITUIDO O NO POR 1-3 HALOGENO, MONOFLUOROMETILO, CF3, DIFLUOROMETOXI, ENTRE OTROS R2 ES ALQUILO C1-C6, CICLOALQUILO C3-C6, HETEROCICLILO DE 4-6 MIEMBROS, FENILO, HETEROARILO DE 5-6 MIEMBROS, ENTRE OTROS R3 ES ALQUILO C1-C6, ALCOXI C1-C6, ALQUILAMINO C1-C6, CICLOALQUILO C3-C7, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (3-{3-[CICLOPROPIL(METIL)AMINO]-1,2,4-OXADIAZOL-5-IL}-5-[4-(TRIFLUOROMETIL)FENIL]PIPERIDIN-1-IL)(MORFOLIN-4-IL)METANONA MORFOLIN-4-IL-{3-[3-(PIPERIDIN-1-IL)-1,2,4-OXADIAZOL-5-IL]-5-[4-(TRIFLUOROMETIL)FENIL]PIPERIDIN-1-IL}METANONA ENTRE OTROS. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO Y/O PROFILAXIS DE TRASTORNOS CARDIOVASCULARES, TROMBOEMBOLITICOS Y/O TRASTORNOS TUMORALES
