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Substituted 1,2,3,4- (tetrahydrocyclopenta [b] indole-3-yl) acetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders
专利权人:
Arena Pharmaceuticals; Inc.
发明人:
JONES, Robert M.,BUZARD, Daniel J.,HAN, Sangdon,KIM, Sun Hee,LEHMANN, Juerg,ULLMAN, Brett,MOODY, Jeanne V.,ZHU, Xiuwen,STIRN, Scott
申请号:
ES09788983
公开号:
ES2589731T3
申请日:
2009.07.22
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
A compound selected from the compounds of Formula (Ia) and pharmaceutically acceptable salts, solvates and hydrates thereof: ** Formula ** in which: m is 1; n is 1 or 2; Y is N or CR1; Z is N or CR4; R3 is C3-C7 cycloalkyl; and each of R1, R2 and R4 is independently selected from H, C1-C6 alkoxy, C1-C6 alkyl, C1-C6 alkylamino, C1-C6 alkylsulfonyl, C1-C6 alkylthio, carboxamide, cyano, C3-C7 cycloalkoxy, cycloalkyl C3-C7, C1-C6 haloalkoxy, C1-C6 haloalkyl, halogen, heteroaryl and heterocyclyl, wherein said C1-C6 alkyl and C1-C6 alkoxy are each optionally substituted with one or two substituents selected from C3-C7 cycloalkyl and halogen .Un compuesto seleccionado entre los compuestos de Formula (Ia) y sales, solvatos e hidratos farmaceuticamente aceptables de los mismos:**Fórmula** en la que: m es 1; n es 1 o 2; Y es N o CR1; Z es N o CR4; R3 es cicloalquilo C3-C7; y cada uno de R1, R2 y R4 se selecciona independientemente entre H, alcoxi C1-C6, alquilo C1-C6, alquilamino C1-C6, alquilsulfonilo C1-C6, alquiltio C1-C6, carboxamida, ciano, cicloalcoxi C3-C7, cicloalquilo C3-C7, haloalcoxi C1-C6, haloalquilo C1-C6, halogeno, heteroarilo y heterociclilo, en donde dichos alquilo C1-C6 y alcoxi C1-C6 estan cada uno opcionalmente sustituidos con uno o dos sustituyentes seleccionados entre cicloalquilo C3-C7 y halogeno.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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