PARK, JOHN EDWARD,CHAUDHARY, NVEED,ROTH, GERALD JUERGEN,HECKEL, ARMIN,DAHMANN, GEORG,GRAUERT, MATTHIAS,BRANDL, TRIXI,PARK, John Edward,CHAUDHARY, Nveed,ROTH, Gerald JĂĽrgen,HECKEL, Armin,DAHMANN, Georg,GRAUERT, Mat
申请号：
RSP20130037
公开号：
RS52653B
申请日:
2005.12.21
申请国别(地区):
RS
年份:
2013
代理人:
摘要：
Indolinona refers to compounds of formula I, where X is o or s； r1 is H or a prodrug is carboxy Group； R2, C1 - C6 carbonyl alkoxy, among others； R3 is C1 - C6 h, alkyl, cycloalkyl C3 - C7, among others； R4 is cycloalkyl C3 - C7； R6 h, F, cyano, amino, among others； R5 C1 - C3 is H, alkyl, Tre.Preferred compounds are: Z - 3 - [1 - (4 - (piperidin-1-yl - anilino methyl) phenyl) methylene] - 1 - 6 - 2 - indolinona Ethoxycarbonyl -, Z - [3 - (1 - (4 - (piperidin-1-yl - anilino methyl) phenyl) methylene] - 1 - 6 - 2 - carbamoyl - indolinona, among others. It also relates to a Pharmaceutical composition. These compounds are useful for the Treatment or prevention of fibrotic Diseases specificJedinjenje 3-Z-[1-(4-(N-((4-metil-piperazin-1-il)-metilkarbonil)-N-metil-amino)-anilino)-1-fenilmetilen]-6-metoksikarbonil-2-indolinon ili njegov tautomer, diastereomer, enantiomer, njegove smeše ili njegova so, za primenu u prevenciji ili lečenju idiopatske plućne fibrozePrijava sadrži još 1 patentni zahtev.
