HACHTEL, Stephanie,WOHLFART, Paulus,WESTON, John,MÜLLER, Marco,DEFOSSA, Elisabeth,MERTSCH, Katharina,WENG, Jian-Hui,BINNIE, Robert A.,ABDUL-LATIF, Farid,BOCK, William Jerome,WALSER, Armin
申请号：
ES13763087
公开号：
ES2623528T3
申请日:
2013.09.19
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of the formula I, ** Formula ** in which R ', R ", R'" are independently from each other H, halogen, CF3, OCF3, O-(C1-C3) alkyl； R1 is a) (C4-C7) alkyl； b) C5-C7 cycloalkyl, which is not substituted or is mono-substituted with (C1-C2) alkyl or CF3； c) methylene cyclohexyl； d) phenyl, which is not substituted or is mono-substituted with methyl or Cl； R2 is a) a 5-membered heteroaryl containing 1 or 2 identical or different ring heteroatoms chosen from N, O and S, wherein said 5-membered heteroaryl is unsubstituted or monosubstituted with Cl or (C1-C4) alkyl ； b) phenyl； c) cycloalkyl (C5-C6)； or d) tetrahydrofuranyl； R3 is H or (C1-C2) alkyl； and R4 is a) (C3-C5) alkyl, which may be optionally substituted with 1-3 F or S-(C1-C4) alkyl, b) (C0-C1) -alkyl (C3-C7) alkyl, wherein said cycloalkyl is not substituted or is mono- or disubstituted with methyl； c) (C0-C2) -phenyl alkylene, wherein said phenyl is not substituted or is mono- or disubstituted with F, Cl, (C1-C4) -alkyl or CF3； or d) thienyl； or R3 and R4 are, together with the carbon atom to which they are attached, a 5- to 7-membered cycloalkyl ring, which is not substituted or is mono-substituted with (C1-C4) alkyl； R5 is H, (C1-C4) alkyl or OH； R6 H or (C1-C4) alkyl； n is 0.1 or 2； and Z is CO2-R7, OR8, C (O) NR9R10, S (O) 2NR11R12, ** Formula ** where v is 0 or 2； R7 is H or (C1-C4) alkyl； R8 is H or (C1-C4) alkyl； R9 is H, (C1-C4) alkyl or ethylene-O-C1-C4 alkyl； and R10 is a) H； b) (C1-C6) alkyl, which is not substituted or monosubstituted with CF3； c) (C1-C2) alkyl, which is substituted with CN or CO2R19 wherein R19 is H or (C1-C6) alkyl； d) (C2-C4) alkyl, which is monosubstituted with a substituent selected from the group consisting of S-methyl, SO2NR20R21, O-R22 and NR23R24； where R20 is H； R21 is H； R22 is H, (C1-C3) alkyl, methylene-cyclopropyl, methylene-phenyl or methylene-2-tetrahydrofuran； R23 is H or (C1-C2) alkyl； R24 is (C1-C2) alkyl or SO2-methyl；Un compuesto de la fórmula I,**Fórmul
