AHN, KAY,BOEHM, MARKUS,CABRAL, SHAWN,CARPINO, PHILIP A.,FUTATSUGI, KENTARO,HEPWORTH, DAVID,KUNG, DANIEL W.,ORR, SUVI,WANG, JIAN
申请号：
PE0015272014
公开号：
PE21642014A1
申请日:
2013.03.26
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Relates to Heterocyclic compounds of formula (i) where a is o, S, among others b is a Link, oxetanilo, among others c and D are each N or CH, CF, C (CH3) r1 is heterociclilo - C (o) -, - C (o) - nr4r5 or heteroaryl, R4 and R5 are where each h, alkyl (c1-c4), cycloalkyl (C3 C6), ariloxi, ent Re R2 is alkyl (c1-c4), alkoxy (c1-c4), cycloalkyl (C3, C6)Among others R3 is alkyl (c1-c4), cycloalkyl (C3 C6), Fluorine or hydroxyl n is 0 to 2.Preferred compounds are: (1) - (2 - (1 - (4 - fluoro - 1H pyrazol-1-yl) cyclopropyl) - 3h imidazo [4,5-b] pyridin - 5 - 3 - il) piperidin yl) (pyrrolidin-1-yl) methanone (1 - (- 8 (1 - (4 - chlorine - 1H pyrazol-1-yl) cyclopropyl) - 9h purin - 2 - il) piperidin yl) 3 - (pyrrolidin-1-yl) methanone 2 - ((1 - (1 - (4 - chlorine - 1H pyrazol-1-yl) cyclopropyl) - 3h Imidazo [4,5-b] pyridin - 5 - il) piperidin yl) 3 - (pyrrolidin-1-yl) methanone among others.It also relates to a Pharmaceutical composition. These compounds are inhibitors of the activity of diacylglycerol acyltransferase 2 (DGAT2) being useful in the treatment of diabetes, hyperlipidemia, ObesitySE REFIERE A COMPUESTOS HETEROCICLICOS DE FORMULA (I) DONDE A ES O, S, ENTRE OTROS B ES UN ENLACE, OXETANILO, ENTRE OTROS C Y D SON CADA UNO N, CH, CF O C(CH3) R1 ES -C(O)-HETEROCICLILO, -C(O)-NR4R5 O HETEROARILO, EN DONDE R4 Y R5 SON CADA UNO H, ALQUILO(C1-C4), CICLOALQUILO(C3-C6), ARILOXI, ENTRE OTROS R2 ES ALQUILO(C1-C4), ALCOXI(C1-C4), CICLOALQUILO(C3-C6), ENTRE OTROS R3 ES ALQUILO(C1-C4), CICLOALQUILO(C3-C6), HIDROXILO O FLUOR n ES DE 0 A 2. SON COMPUESTOS PREFERIDOS: (1-(2-(1-(4-FLUORO-1H-PIRAZOL-1-IL)CICLOPROPIL)-3H-IMIDAZO[4,5-b]PIRIDIN-5-IL)PIPERIDIN-3-IL)(PIRROLIDIN-1-IL)METANONA (1-(8-(1-(4-CLORO-1H-PIRAZOL-1-IL)CICLOPROPIL)-9H-PURIN-2-IL)PIPERIDIN-3-IL)(PIRROLIDIN-1-IL)METANONA (1-(2-(1-(4-CLORO-1H-PIRAZOL-1-IL)CICLOPROPIL)-3H-IMIDAZO[4,5-b]PIRIDIN-5-IL)PIPERIDIN-3-IL)(PIRROLIDIN-1-IL)METANONA ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS
