EASTWOOD, PAUL ROBERT,BACH TANA, JORDI,PAGES SANTACANA, LLUIS MIQUEL
申请号：
PE0000842014
公开号：
PE14092014A1
申请日:
2012.07.23
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Relates to compounds of formula (i) wherein: M is 0, 1, 2 or 3 X and y are independent or - Cr6 a and B are independently n o n - d or - CR7 CR5 W is a Linker Group selected or nr8 -, S -, other R5 and R6 are independently h, halogeno, cyano, haloalquilo c1-c4, cicloa Lquilo C3 - C10, among others R7 is H, halogeno, cyano, cycloalkyl C3 - C10, R8 is H, among othersHaloalquilo hidroxialquilo C1 - C4, C1 - C4, among others r1 is H, hidroxialquilo C1 - C4, C1 - C4 alkoxy, among others R2 is H, halogen, cicloalquenilo C3 - C10, among others R3 and R4 are independently h, haloalquilo c1-c4 hidroxialquilo c1-c4 alkyl, or linear or branched C1 - C6.Preferred compounds are: (S) - 3 - (4 - (1 - (5 - fluoropiridin - 2 - il) ethylamino) - 2 - ilamino pyridin pyrimidin-2-yl) - 2 (1H) - One 3 - oxo - (R) - 3 - (3 - (2 - (2 - oxo - 1.2 - dihidropiridin - 3 - ilamino pyrimidin-2-yl) - 4 - ilamino) piperidin-1-yl) propanenitrile among others. It also relates to a Pharmaceutical Composition and a combination.These Compound are useful for the treatment of Multiple sclerosis, rheumatoid arthritis, Asthma, psoriasis, atopic dermatitisSE REFIERE A COMPUESTOS DE FORMULA (I) DONDE: m ES 0, 1, 2 O 3 X E Y SON INDEPENDIENTEMENTE N O -CR6 A Y B SON INDEPENDIENTEMENTE N O -CR7 D ES N O -CR5 W ES UN GRUPO ENLAZADOR SELECCIONADO DE O, S, -NR8-, ENTRE OTROS R5 Y R6 SON INDEPENDIENTEMENTE H, HALOGENO, CIANO, HALOALQUILO C1-C4, CICLOALQUILO C3-C10, ENTRE OTROS R7 ES H, HALOGENO, CIANO, CICLOALQUILO C3-C10, ENTRE OTROS R8 ES H, HALOALQUILO C1-C4, HIDROXIALQUILO C1-C4, ENTRE OTROS R1 ES H, HIDROXIALQUILO C1-C4, ALCOXI C1-C4, ENTRE OTROS R2 ES H, HALOGENO, CICLOALQUENILO C3-C10, ENTRE OTROS R3 Y R4 SON INDEPENDIENTEMENTE H, HALOALQUILO C1-C4, HIDROXIALQUILO C1-C4 O ALQUILO LINEAL O RAMIFICADO C1-C6. SON COMPUESTOS PREFERIDOS: (S)-3-(4-(1-(5-FLUOROPIRIDIN-2-IL)ETILAMINO)PIRIMIDIN-2-ILAMINO)PIRIDIN-2(1H)-ONA (R)-3-OXO-3-(3-(2-(2-OXO-1,2-DIHIDROPIRIDIN-3-ILAMINO)PIRIMIDIN-4-ILAMINO)PIPERIDIN-1-IL)PROPAN
