BROWN, MATHEW FRANK,CHE, YE,MELNICK, MICHAEL JOSEPH,MONTGOMERY, JUSTIN IAN,PLUMMER, MARK STEPHEN,PRICE, LOREN MICHAEL,REILLY, USA
申请号：
PE0020162013
公开号：
PE03972014A1
申请日:
2012.02.22
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Refers to fluoro pyridinone derivative compounds of formula (i) wherein R1 is alkyl (C1 - C3) R2 is H or alkyl (C1 - C3) R3 is H, halogen, Hydroxy, CN, among others t is etinilo (C6 C10, aryl or heteroaryl is absent (d) or is it A Link, (CH2) R or N - (CH2) or - (CH2) P, where r is 1 to 3 n and P Each of 0 to 2, and is absent or cycloalkyl, aryl (C3 - C10) (C6 C10), among others.Preferred compounds are: {(2R) - 4 - 5 - fluoro - 2 - oxo - 4 - [4 - (2H - 1,2,3 triazol - il - 2) phenyl] pyridin-3 (2H) - il - 1} - N - hydroxy - 2 - methyl - 2 - (methylsulfonyl) butanamide (2R) - 4 - 5 - fluoro - [4 - (2 - fluoro - 4-methoxyphenyl) - 2 - oxopiridin - 1 (2H) - yl] - N - hydroxy - 2 - methyl - 2 - (methylsulfonyl) butanamide, among others. It also relates to a Pharmaceutical composition.These compounds are antibacterial against Gram negative being particularly useful in the treatment of bacterial infectionsSE REFIERE A COMPUESTOS DERIVADOS DE FLUORO-PIRIDINONA DE FORMULA (I) DONDE R1 ES ALQUILO(C1-C3) R2 ES H O ALQUILO(C1-C3) R3 ES H, HALOGENO, HIDROXI, CN, ENTRE OTROS T ES ETINILO, ARILO(C6-C10) O HETEROARILO D ESTA AUSENTE O ES UN ENLACE, (CH2)r O (CH2)n-O-(CH2)p, EN DONDE r ES DE 1 A 3 n Y p SON CADA UNO DE 0 A 2 E ESTA AUSENTE O ES CICLOALQUILO(C3-C10), ARILO(C6-C10), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (2R)-4-{5-FLUORO-2-OXO-4-[4-(2H-1,2,3-TRIAZOL-2-IL)FENIL]PIRIDIN-1(2H)-IL}-N-HIDROXI-2-METIL-2-(METILSULFONIL)BUTANAMIDA (2R)-4-[5-FLUORO-4-(2-FLUORO-4-METOXIFENIL)-2-OXOPIRIDIN-1(2H)-IL]-N-HIDROXI-2-METIL-2-(METILSULFONIL)BUTANAMIDA ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTIBACTERIANOS EN ESPECIAL CONTRA GRAM-NEGATIVOS SIENDO UTILES EN EL TRATAMIENTO DE INFECCIONES BACTERIANAS
