KUHNERT, SVEN,MERLA, BEATRIX,KLESS, ACHIM,BAHRENBERG, GREGOR,SCHRODER, WOLFGANG
申请号：
PE0015962011
公开号：
PE06672012A1
申请日:
2010.03.11
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Refers to compounds of 2 - mercapto - 3 - aminopyridines formula (1) wherein R1 is alkyl, cycloalkyl (C1 - C6) (C3 - C10), aryl, among others R2 is aryl or heteroaryl and S (S = o) 2 (= o) - S, -, - O -, among others R3, R4, R5, r6a, R6B, R7a, R7b, r8a and r8b are each h, F, NO2, CN, CF3, ocf3 Alkyl (C1 - C6), among others M is 0 OR 1.Preferred compounds are: N - [2 - [2 - (benzolsulfonil) - etilsulfanil] pyridin-3-yl] - 2 - Cyclohexyl - acetamide acid amide N - [2 - [2 - [[3 - (trifluoromethyl) phenyl] sulfonyl] - etilsulfanil] pyridin-3-yl] - tiofen - 2 - carboxylic acid n - [2 - (3-phenyl propylsulfanyl) pyridin-3-yl] - 2 - (thiophen-2-yl acetamide among others. It also relates to a Pharmaceutical composition.These compounds are modulators of the K + Channel of heteromeric KCNQ2 \/ 3 molecular subtype being useful in the treatment of Epilepsy, Pain, urinary incontinence, migranaSE REFIERE A COMPUESTOS DERIVADOS DE 2-MERCAPTO-3-AMINOPIRIDINAS DE FORMULA (1) DONDE R1 ES ALQUILO(C1-C6), CICLOALQUILO(C3-C10), ARILO, ENTRE OTROS R2 ES ARILO O HETEROARILO Y ES S(=O)2, S(=O), -S-, -O-, ENTRE OTROS R3, R4, R5, R6a, R6b, R7a, R7b, R8a Y R8b SON CADA UNO H, F, NO2, CF3, CN, OCF3, ALQUILO(C1-C6), ENTRE OTROS m ES 0 O 1. SON COMPUESTOS PREFERIDOS: N-[2-[2-(BENZOLSULFONIL)-ETILSULFANIL]-PIRIDIN-3-IL]-2-CICLOHEXIL-ACETAMIDA AMIDA DE ACIDO N-[2-[2-[[3-(TRIFLUOROMETIL)FENIL]SULFONIL]-ETILSULFANIL]-PIRIDIN-3-IL]-TIOFEN-2-CARBOXILICO N-[2-(3-FENIL-PROPILSULFANIL)-PIRIDIN-3-IL]-2-TIOFEN-2-IL-ACETAMIDA ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DEL CANAL DE K+ HETEROMERICO DEL SUBTIPO MOLECULAR KCNQ2/3 SIENDO UTILES EN EL TRATAMIENTO DEL DOLOR, EPILEPSIA, INCONTINENCIA URINARIA, MIGRANA
