CRAWFORD, JAMES JOHN,ORTWINE, DANIEL FRED,WEI, BINQING,YOUNG, WENDY B.
申请号：
PE0006382014
公开号：
PE15862014A1
申请日:
2012.11.02
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Relates to compounds of formula (i), wherein: N is X1 or x2 is CR1, CR2 and Cr3 or X3 is n n where one or two X1, x2 and X3 are n R1, R2 and R3 are independently h, F, CL - NH2, - OCH3, - Oh, alkyl C1 - C3 - nhch3, among others R4 is H, F, CL, CN, - CH2OH, among others R5 is hetero aryl C6 C20 Ciclilo heteroaryl C1 - C2 - C20 and C20, among others R6 h, CH3, oh - CH2CH3, among others R7 IS)(b) where, among others, the Wavy Line indicates the binding site y1 and Y2 are ch and N independently. Also refers to a Pharmaceutical composition. These compounds are useful for the treatment of cancer, cardiovascular disease, viral infection, Neurological DisordersSE REFIERE A COMPUESTOS DE FORMULA (I), EN DONDE: X1 ES CR1 O N X2 ES CR2 O N X3 ES CR3 O N DONDE UNO O DOS DE X1, X2 Y X3 SON N R1, R2 Y R3 SON INDEPENDIENTEMENTE H, F, Cl -NH2-, -OCH3, -OH, ALQUILO C1-C3, -NHCH3, ENTRE OTROS R4 ES H, F, Cl, CN, -CH2OH, ENTRE OTROS R5 ES ARILO C6-C20, HETEROCICLILO C2-C20, HETEROARILO C1-C20, ENTRE OTROS R6 ES H, -CH3, -CH2CH3, -OH, ENTRE OTROS R7 ES a), b), ENTRE OTROS, DONDE LA LINEA ONDULADA INDICA EL SITIO DE UNION Y1 E Y2 SON INDEPENDIENTEMENTE CH Y N. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON UTILES PARA EL TRATAMIENTO DE CANCER, ENFERMEDAD CARDIOVASCULAR, INFECCION VIRAL, TRASTORNOS NEUROLOGICOS
