BAILEY, SIMON,BURKE, BENJAMIN JOSEPH,COLLINS, MICHAEL RAYMOND,CUI, JINGRONG JEAN,DEAL, JUDITH GAIL,HOFFMAN, ROBERT LOUIS,HUANG, QINHUA,JOHNSON, TED WILLIAM,KANIA, ROBERT STEVEN,KATH, JOHN CHARLES,LE,
申请号：
PE0013292014
公开号：
PE23392014A1
申请日:
2013.02.20
申请国别(地区):
PE
年份:
2015
代理人:
摘要：
Macrociclico refers to a compound of formula (i), where X is - (cr5r6 qo (R) - (- cr5r6), cr5r6) QN (R1) (cr5r6) R, among others and Z is CH or a Ring a is selected from aryl and heteroaryl C6 C12 5 to 6 members r1 is H, alkyl of C1 - C6, alquenilo C2 - C6, alquinilo C2 - C6, among others R2 is haloge No, I alquenilo C6 C1, C2 - C6, among others R3 and R4 are C1 - C6 h, alkyl, cycloalkyl C3 C6Among others, R5 and R6 are h, alkyl of C1 - C6, alquenilo C2 - C6, Oh, among others M and N are 0, 1, 2 or 3 and P is 0, 1, 2, 3 or 4. It also relates to a Pharmaceutical composition. These compounds inhibit the anaplastic Lymphoma Kinase (alk) and \/ or eml4-alk and are useful in the treatment of abnormal Cellular proliferative Disorders such as cancerREFERIDA A UN COMPUESTO MACROCICLICO DE FORMULA (I), DONDE X ES -(CR5R6)qO(CR5R6)r-, -(CR5R6)qN(R1)(CR5R6)r, ENTRE OTROS Y Y Z SONN O CH A ES UN ANILLO SELECCIONADO DE ARILO C6-C12 Y HETEROARILO DE 5 A 6 MIEMBROS R1 ES H, ALQUILO C1-C6, ALQUENILO C2-C6, ALQUINILO C2-C6, ENTRE OTROS R2 ES HALOGENO, ALQUILO C1-C6, ALQUENILO C2-C6, ENTRE OTROS R3 Y R4 SON H, ALQUILO C1-C6, CICLOALQUILO C3-C6, ENTRE OTROS R5 Y R6 SON H, ALQUILO C1-C6, ALQUENILO C2-C6, OH, ENTRE OTROS m Y n SON 0, 1, 2 O 3 p ES 0, 1, 2, 3 O 4. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS INHIBEN LA QUINASA DEL LINFOMA ANAPLASICO (ALK) Y/O EML4-ALK Y SON UTILES EN EL TRATAMIENTO DE TRASTORNOS PROLIFERATIVOS CELULARES ANORMALES TALES COMO EL CANCER
