It refers to compounds of formula I, where: V, W, Y and Z are CH or CR2； R1 is C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, among others； R2 is halogen, C1-C3 alkyl, C1-C3 haloalkyl, among others； R3 is C2-C6 or R4 hydroxyalkyl； R4 is (C2-C6 alkyl) -OC (= O) -C (H) (R5) -N (H) C (= O) -C (H) (R7) -NH2. Preferred compounds are: 2-2- {4 - [(3- {4 - [(3-chloropyridin-4-yl) amino] -5-methoxypyrimidin-2-yl} -1H-indazol-1-yl) methyl] -3,5-difluorophenoxy} ethanol, 2- {3,5-difluoro-4 - [(3- {5-methoxy-4 - [(2-methylpyridin-4-yl) amino] pyrimidin-2-yl} - 1H-indazol-1-yl) methyl] phenoxy} ethanol, 2- {3,5-difluoro-4 - [(3- {5-methoxy-4 - [(3-methoxypyridin-4-yl) amino] pyrimidin- 2-yl} -1H-indazol-1-yl) methyl] phenoxy} ethanol,There are others These compounds inhibit quinolase BB1 and can be used to treat diffuse disorders.Se refiere a compuestos de formula I, en donde: V, W, Y y Z son CH o CR2； R1 es alquilo C1-C6, haloalquilo C1-C6, cicloalquilo C3-C6, entre otros； R2 es halogeno, alquilo C1-C3, haloalquilo C1-C3, entre otros； R3 es hidroxialquilo C2-C6 o R4； R4 es (alquilo C2-C6)-OC(=O)-C(H)(R5)-N(H)C(=O)-C(H)(R7)-NH2. Son compuestos preferidos: 2-2-{4-[(3-{4-[(3-cloropiridin-4-il)amino]-5-metoxipirimidin-2-il}-1H-indazol-1-il)metil]-3,5-difluorofenoxi}etanol, 2-{3,5-difluoro-4-[(3-{5-metoxi-4-[(2-metilpiridin-4-il)amino]pirimidin-2-il}-1H-indazol-1-il)metil]fenoxi}etanol, 2-{3,5-difluoro-4-[(3-{5-metoxi-4-[(3-metoxipiridin-4-il)amino]pirimidin-2-il}-1H-indazol-1-il)metil]fenoxi}etanol, entre otros. Dichos compuestos inhiben la quinasa Bub1 y son utiles en el tratamiento de trastornos proliferativos
