RODGERS, JAMES D.,SHEPARD, STACEY,ZHU, WENYU,SHAO, LIXIN,GLENN, JOSEPH
申请号：
PE2013001220
公开号：
PE20140146A1
申请日:
2011.11.18
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
It refers to the compounds of pyrethroids and pyrethroids derivatives, replaced by one (I), where x and W are ch or N； and h, CN, hydrocarbon (C1-C3),Among other things, l is O, s, C (= O),C (= O) or, among other things, Z is Cr4 or N； R1, R2, R3 and R4 are h, hydroxy, halogen and hydrocarbyl (C1-C3), respectively,R5 is, among other things, hydroxyl, oxygen (C1-C4),F, asphalt (C1-C4),Among other things, a is h, asphalt (C1-C6),Cyclopropyl (C3-C10),Arilo（C6-C10），Among other things, M is from 0 to 2 and N is from 0 to 4. 4 - [4 - [4 - [4 - [4 - (1-1-1-1-1-1-1-1-pir1-pir1-1-methyl] - 6 - (dimethylamine) - 2-fluorobenzoonitrilo； 4 - {3 - (cyanomethyl) - 3 - [4 - (7h pirrolo [2], 3-d] pyridine-4-il-1h-pirazol-1-il] cycloutil} - N - [4-FLUORO-2 - (trifluoro octane sulfonic acid) phenyl] pyridine-1-carboxamida, etc. He also mentioned a pharmaceutical composer These compounds are inhibitors of quinas (JAK) for the treatment of multiple sclerosis and rheumatoid arthritis.Cancer, fearSE REFIERE A COMPUESTOS DERIVADOS DE PIRROLOPIRIDINA Y PIRROLOPIRIMIDINA SUSTITUIDOS CON CICLOBUTILO DE FORMULA (I) DONDE X Y W SON CADA UNO CH O N； Y ES H, CN, ALQUILO(C1-C3), ENTRE OTROS； L ES O, S, C(=O), C(=O)O, ENTRE OTROS； Z ES CR4 O N； R1, R2, R3 Y R4 SON CADA UNO H, HIDROXI, HALO, ALQUILO(C1-C3), ENTRE OTROS； R5 ES HIDROXI, ALCOXI(C1-C4), F, ALQUILO(C1-C4), ENTRE OTROS； A ES H, ALQUILO(C1-C6), CICLOALQUILO(C3-C10), ARILO(C6-C10), ENTRE OTROS； m ES DE 0 A 2； n ES DE 0 A 4. SON COMPUESTOS PREFERIDOS: 3-[(4-{3-(CIANOMETIL)-3-[4-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL]CICLOBUTIL}PIPERAZIN-1-IL)METIL]-5-FLUOROBENZONITRILO； 3-[(4-{3-(CIANOMETIL)-3-[4-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL]CICLOBUTIL}PIPERAZIN-1-IL)METIL]-6-(DIMETILAMINO)-2-FLUOROBENZONITRILO； 4-{3-(CIANOMETIL)-3-[4-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL]CICLOBUTIL}-N-[4-FLUORO-2-(TRIFLUOROMETIL)FENIL]PIPERAZIN-1-CARBOXAMIDA； ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS C
