FLIRI ANTON FRANZ JOSEPH,GALLASCHUN RANDALL JAMES,O'DONELL CHRISTOPHER JOHN,SCHWARZ JACOB BRADLEY,SEGELSTEIN BARBARA EILEEN
申请号：
PE2011002171
公开号：
PE20120329A1
申请日:
2010.06.22
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
It refers to the compounds produced from the acyclic formula (I) sulfamide, wherein R1, R2 and R7 are respectively h, halogenated, hydroxy, CF3 and hydrocarbyl (C1-C6),Among them, R3 and R5 are h or tar (C1-C6), respectively；R4 is h or tar (C1-C6), which can be replaced by halogenation, but in other ways； R6 is tar (C1-C6) - (C = O),[asphalt (C1-C6)] 2n - (C = O) - (asphalt (C1-C6)) - SO2 -,cycloquil（C3-C10）-SO2-，Ring a is arilo (C6-C10), among other things,Heteromorphic (c4-c10),Ring B is arilo (C6-C10), among other things,Cyclopropyl (c4-c10),a. Among other things, heterosexual； X is o or C (R4) 2； missing or C = O, or, among other things, Z is O, s, (s = O) or (SO2)；M. N, P and Q are 0 to 3 respectively； s and T are 1 or 2 respectively. - 5-6-6-6-6-6-6-6-6]] - from 1-1-1-1-1-1-1-1-1-1-1-1-1 - propane-2-sulfosamide, etc. He also mentioned a pharmaceutical composer These compounds can be used to treat neurodegeneration related to glutamate dysfunction, such as cerebral ischemia, Alzheimer's disease, and lateral amoxic sclerosis.SE REFIERE A COMPUESTOS DERIVADOS DE SULFONAMIDAS HETEROCICLICAS DE FORMULA (I) DONDE R1, R2 Y R7 SON CADA UNO H, HALOGENO, HIDROXILO, CF3, ALQUILO(C1-C6), ENTRE OTROS； R3 Y R5 SON CADA UNO H O ALQUILO(C1-C6)； R4 ES H O ALQUILO(C1-C6) OPCIONALMENTE SUSTITUIDO CON HALOGENO, CN, ENTRE OTROS； R6 ES ALQUILO(C1-C6)-(C=O), [ALQUIL(C1-C6)]2N-(C=O)-(ALQUIL(C1-C6))-SO2-, CICLOALQUIL(C3-C10)-SO2-, ENTRE OTROS； EL ANILLO A ES ARILO(C6-C10), HETEROARILO, CICLOALQUILO(C4-C10), ENTRE OTROS； EL ANILLO B ES ARILO(C6-C10), CICLOALQUILO(C4-C10), HETEROCICLOALQUILO, ENTRE OTROS； X ES O U C(R4)2； Y ESTA AUSENTE O ES -C=O, O, ENTRE OTROS； Z ES O, S, (S=O) O (SO2)； m, n, p Y q SON CADA UNO DE 0 A 3； s Y t SON CADA UNO 1 O 2. SON COMPUESTOS PREFERIDOS: [(3S,4S)-4-(2'-CIAN-BIFENIL-4-ILOXI)-TETRAHIDRO-FURAN-3-IL]-AMIDA DEL ACIDO PROPAN-2-SULFONICO； {(1S,2R)-2-[4-(5-CIAN-TIOFEN-2-IL)-FENOXI]-CICLOPENTIL}-AMIDA DEL ACIDO PROPAN-2-SULFONICO； {(1S,2R)-2-[6-(5-CIAN-TIO
