FLIRI ANTON FRANZ JOSEPH,GALLASCHUN RANDALL JAMES,ODONELL CHRISTOPHER JOHN,SCHWARZ JACOB BRADLEY,SEGELSTEIN BARBARA EILEEN
申请号：
PE0021712011
公开号：
PE03292012A1
申请日:
2010.06.22
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Relates to Heterocyclic sulfonamide compounds of formula (i) where R1, R2 and R6 are each h, halogen, CF3, hydroxyl, alkyl (C1 - C6), among others R3 and R5 are each H or alkyl (C1 - C6) R4 is H or alkyl (C1 - C6 optionally substituted by Halogen, CN), among others, the R6 Chilo (C1 - C6) - (c = o), [alkyl (C1 - C6) 2n - (c = o) - (alkyl (C1 - C6) - SO2 -, cicloalquil (C3 - C10) - SO2 -,Among others, the ring a is aryl, heteroaryl (C6 C10), cycloalkyl (C4 - C10), among others the aryl Ring B (C6 C10), cycloalkyl (C4, C10) heterocicloalquilo, among others X is o or C (R4) is absent or is 2 and - C = o, o, among others Z is o, S (S = o) or (SO2) m, N, P and q are each of 0 to 3 and T are each 1 or 2.Preferred compounds are: [(3S, 4S) - 4 - (2 - Cyan - Diphenyl - 4 - iloxi) - tetrahydro - furan - 3 - yl] - amide PROPENE sulfonic acid - 2 - {, (1S, 2R) - 2 - [4 - (5 - Cyan - tiofen - 2 - IL) - phenoxy] - ciclopentil} - amide PROPENE sulfonic acid - 2 - {, (1S, 2R) - 2 - [6 - (5 - Cyan - thiophen-2-yl) - pyridin - 3 - iloxi}] - cyclohexyl amide acid prop - An - 2 - sulfonic acid among others. It also relates to a Pharmaceutical composition.These compounds are useful in the treatment of Neurological Disorders associated with dysfunction of glutamate such as cerebral ischemia, Alzheimers disease, Amyotrophic lateral sclerosisSE REFIERE A COMPUESTOS DERIVADOS DE SULFONAMIDAS HETEROCICLICAS DE FORMULA (I) DONDE R1, R2 Y R7 SON CADA UNO H, HALOGENO, HIDROXILO, CF3, ALQUILO(C1-C6), ENTRE OTROS R3 Y R5 SON CADA UNO H O ALQUILO(C1-C6) R4 ES H O ALQUILO(C1-C6) OPCIONALMENTE SUSTITUIDO CON HALOGENO, CN, ENTRE OTROS R6 ES ALQUILO(C1-C6)-(C=O), [ALQUIL(C1-C6)]2N-(C=O)-(ALQUIL(C1-C6))-SO2-, CICLOALQUIL(C3-C10)-SO2-, ENTRE OTROS EL ANILLO A ES ARILO(C6-C10), HETEROARILO, CICLOALQUILO(C4-C10), ENTRE OTROS EL ANILLO B ES ARILO(C6-C10), CICLOALQUILO(C4-C10), HETEROCICLOALQUILO, ENTRE OTROS X ES O U C(R4)2 Y ESTA AUSENTE O ES -C=O, O, ENTRE OTROS Z ES O, S, (S=O) O (SO2) m, n, p Y q SON C
