GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
发明人:
ANDERSON, Niall Andrew,BANDYOPADHYAY, Deepak,DAUGAN, Alain Claude-Marie,DONCHE, Frederic G.,EIDAM, Patrick M.,FAUCHER, Nicolas Eric,GEORGE, Nicolas S.,HARRIS, Philip Anthony,JEONG, Jae U.,KING, Bryan
申请号：
PE2017002383
公开号：
PE5082018A1
申请日:
2016.05.19
申请国别(地区):
PE
年份:
2018
代理人:
摘要：
It refers to a type of non cyclopentamide, wherein R1 is alcoxi (C1-C4) - CH2 -.Phenyl methoxy (C1-C4) - CH2 -,R2 is, among other things, a group of phenyl, cyclomethyl (C3-C6),among others； R3 is H or halogen. Preferred compounds are: (5- (5-fluoropyridin-3-yl) -4,5-dihydro-1H-pyrazol-1-yl) (1- (5-methylpyrimidin-2-yl) piperidine -4-yl) methanone； (1- (5-fluoropyridin-2-yl) piperidin-4-yl) (5-phenyl-4,5-dihydro-1 H -pyrazol-1-yl) methanone, among others. The present invention is useful for the treatment of diseases mediated by the RIP1 kinase, examples of these diseases are programmed necrosis, psoriasis, atopic dermatitis, among others.Se refiere a amidas heterociclicas de formula I, en donde R1 es alcoxi (C1-C4)-CH2-, fenil-alcoxi(C1-C4)-CH2-, entre otros； R2 es un grupo fenilo, cicloalquilo(C3-C6), entre otros； R3 es H o halogeno Tiene como compuesto preferidos: (5-(5-fluoropiridin-3-il)-4,5-dihidro-1H-pirazol-1-il)(1-(5-metilpirimidin-2-il)piperidin-4-il)metanona； (1-(5-fluoropiridin-2-il)piperidin-4-il)(5-fenil-4,5-dihidro-1H-pirazol-1-il)metanona, entre otros. La presente invencion es util para el tratamiento de enfermedades mediadas por la quinasa RIP1, ejemplos de estan enfermedades son la necrosis programada, psoriasis, dermatitis atopica, entre otras
