GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
发明人:
ANDERSON, Niall Andrew,BANDYOPADHYAY, Deepak,DAUGAN, Alain Claude-Marie,DONCHE, Frederic G.,EIDAM, Patrick M.,FAUCHER, Nicolas Eric,GEORGE, Nicolas S.,HARRIS, Philip Anthony,JEONG, Jae U.,KING, Bryan
申请号：
PE0023832017
公开号：
PE5082018A1
申请日:
2016.05.19
申请国别(地区):
PE
年份:
2018
代理人:
摘要：
Relates to Heterocyclic amides of formula I, wherein R1 is alkoxy (c1-c4) - CH2 -, phenyl alkoxy (c1-c4) - CH2 -, among others R2 is a phenyl Group, cycloalkyl (C3, C6)Among others R3 is H or Halogen Compound is Preferred: (5 - (5 - fluoropiridin - il - 4, - 3)5 - dihydro 1h pyrazol-1-yl) (1 - (5 - metilpirimidin - 2 - il) piperidin-4-yl (IL) methanone 1 - (5 - fluoropiridin - 2 - il) piperidin-4-yl 5 (IL) - phenyl - 4,5-dihydro - 1H pyrazole - 1 - il) methanone, among others.The Invention is useful for the treatment of diseases mediated by kinase RIP1, are examples of diseases are programmed necrosis, psoriasis, atopic dermatitis, among othersSe refiere a amidas heterociclicas de formula I, en donde R1 es alcoxi (C1-C4)-CH2-, fenil-alcoxi(C1-C4)-CH2-, entre otros R2 es un grupo fenilo, cicloalquilo(C3-C6), entre otros R3 es H o halogeno Tiene como compuesto preferidos: (5-(5-fluoropiridin-3-il)-4,5-dihidro-1H-pirazol-1-il)(1-(5-metilpirimidin-2-il)piperidin-4-il)metanona (1-(5-fluoropiridin-2-il)piperidin-4-il)(5-fenil-4,5-dihidro-1H-pirazol-1-il)metanona, entre otros. La presente invencion es util para el tratamiento de enfermedades mediadas por la quinasa RIP1, ejemplos de estan enfermedades son la necrosis programada, psoriasis, dermatitis atopica, entre otras
