NOVEL HYDROXY-6-HEROARYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS

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专利权人:

TAKEDA GMBH

发明人:

HATZELMANN ARMIN,FLOCKERZI DIETER,KLEY HANS-PETER,SCHMIDT BEATE,BARSIG JOHANNES,MARX DEGENHARD,ZITT CHRISTOF

申请号：

NO20064221

公开号：

NO336538B1

申请日:

2006.09.19

申请国别(地区):

NO

年份:

2015

代理人:

摘要：

Compounds of formula I in which R1 is methoxy, R2 is methoxy, ethoxy, difluoromethoxy or 2,2-difluoroethoxy, R3 is hydrogen, R31 is hydrogen, R4 is -O-R41, in which R41 is hydrogen, R5 is hydrogen, Har is substituted by R6 and R7, and is pyridinyl, in which R6 is oxo, and R7 is methyl, or an enantiomer, a salt, a N-oxide or a salt of an enantiomer or N-oxide thereof are novel effective PDE4 inhibitors.

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