Novel hydroxy-6-heroarylphenanthridines and their use as pde4 inhibitors

• 收藏
• 分享

专利权人:

Takeda GmbH

发明人:

Hatzelmann, Armin,Flockerzi, Dieter,Kley, Hans-Peter,Schmidt, Beate,Barsig, Johannes,Marx, Degenhard,Zitt, Christof

申请号：

NO20141541

公开号：

NO338326B1

申请日:

2014.12.18

申请国别(地区):

NO

年份:

2016

代理人:

摘要：

Compounds of formula I in which R1 is methoxy, R2 is methoxy, ethoxy, difluoromethoxy or 2,2-difluoroethoxy, R3 is hydrogen, R31 is hydrogen, R4 is -O-R41, in which R41 is hydrogen, R5 is hydrogen, Har is substituted by R6 and R7, and is pyridinyl, in which R6 is oxo, and R7 is methyl, or an enantiomer, a salt, a N-oxide or a salt of an enantiomer or N-oxide thereof are novel effective PDE4 inhibitors.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/