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Cyclic pyrimidin-4-carboxamides as CCR2 receptor antagonists for the treatment of inflammations, asthma and COPD
专利权人:
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
发明人:
EBEL, HEINER,FRATTINI, SARA,GIOVANNINI, RICCARDO,HOENKE, CHRISTOPH,TRIESELMANN, THOMAS,TIELMANN, PATRICK,SCHEUERER, STEFAN,HOBBIE, SILKE (MARIE KATRIN),BUETTNER, FRANK
申请号:
ES09775212
公开号:
ES2551557T3
申请日:
2009.12.17
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A compound of formula (I), ** Formula ** in which R1 is -L1-R7, and in which L1 is a bond or a group selected from methylene, ethylene and ethenylene, and in which R7 is a ring selected from cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, pyrrolidinyl, piperidinyl, azepanyl, tetrahydrofuranyl, tetrahydropyranyl, oxepanyl, phenyl, pyridyl and furanyl, wherein L1, if different from a bond, is optionally substituted with one or more groups selected from methyl and ethyl, in which the R7 ring is optionally substituted with one or more groups selected from -F, -Cl, -methyl, -ethyl, -propyl, -i-propyl, -cyclopropyl, -t-butyl, -CF3, -O-CF3, -CN, -O-methyl, -furanyl and -phenyl, wherein said furanyl and said phenyl are optionally independently substituted with one or more groups selected from - C1-C6 alkyl, halogen, -OCH3, -CF3 and -OCF3, or in which R7 is bi-valentically substituted with one or more groups os selected from between two neighboring ring atoms so that a re-associated ring is formed; wherein R2 is selected from -H, -halogen, -CN, -O-C1-C4 alkyl, -C1-C4 alkyl, -CH>; = CH2, -C-CH, -CF3, - OCF3, -OCF2H and - OCFH2; wherein R3 is selected from -H, -methyl, -ethyl, -propyl, -i-propyl, -cyclopropyl, -OCH3 and -CN; wherein R4 and R5 are independently selected from a pair of electrons, -H, and a group selected from -C1-C6 alkyl, -NH2, -C3-C8 cycloalkyl, -C3-C8 heterocyclyl, -C5-C10 aryl, - C5-C10 and -C (O) -N (R8, R8 ') heteroaryl, where R8 and R8' are independently selected from -H and -C1-C6 alkyl, and where R4 and R5, if they are different from a electron pair or -H, are optionally independently substituted with one or more groups selected from -halogen, -OH, -CF3, -CN, -C1-C6 alkyl, -O-C1-C6 alkyl, -O-C3 cycloalkyl- C8, -O-C3-C8 heterocyclyl, -O-C5-C10-aryl, -O-C5-C10 heteroaryl, -C0-C6-CN alkylene, -C0-C4-O-C1-C4 alkylene, -C0 alkylene -C4-O-C3-C8 cycloalkyl, -C0-C4-O-C3-C8-alkylene, - C0-C4-O-aryl-C5-C10-alkylene, C0-C4-O-C5-C10-alkylene, - C0-
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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