IOANNIDIS, Stephanos,TALBOT, Adam Charles,FOLLOWS, Bruce,BUCKMELTER, Alexandre Joseph,WANG, Minghua,CAMPBELL, Ann-Marie,SCHMIDT, Darby Rye,GUERIN, David Joseph,CARAVELLA, Justin A.,DIEBOLD, R. Bruce,E
申请号：
ES15832772
公开号：
ES2768996T3
申请日:
2015.12.29
申请国别(地区):
ES
年份:
2020
代理人:
摘要：
A compound having the Formula (Ig) or (Ih): ** (See formula) ** or a pharmaceutically acceptable salt thereof, wherein: R2 is (C1-C8) alkyl, aryl, heteroaryl, (C3-C8 ) cycloalkyl, heterocyclyl, -NR10R11 or -OR10, wherein alkyl, aryl, cycloalkyl and heterocyclyl are optionally substituted with one or more R8； R4 is (C1-C6) alkyl, - (C0-C3) alkylene-aryl, heteroaryl, (C3-C8) cycloalkyl, CD3, or heterocyclyl, where aryl, heteroaryl, heterocyclyl, and cycloalkyl are optionally substituted with one or more R12 ； each R8 is independently at each occurrence selected from D, (C1-C6) alkyl, (C1-C6) alkoxy, (C1-C6) haloalkyl, (C1-C6) haloalkoxy, - (C1-C3) -alkylene-O ( C1-C6) alkyl, - (C0-C4) -alkylene-aryl, - (C0-C4) -alkylene-heteroaryl, (C3-C10) cycloalkyl, heterocyclyl, - (C0-C4) -alkylene-O-aryl, - (C0-C4) -alkylene-O-heteroaryl, -O- (C3-C8) cycloalkyl, -S-heteroaryl, halogen, -CN, -C (O) R10, -CO (O) R10, -C ( O) NR10R11, -S (O) qR10, -S (O) qNR10R11, -NR10S (O) qR11, - (C0-C3) -alkylene-NR10R11, -NR10C (O) R11, -NR10C (O) C ( O) R11, -NR10C (O) NR10R11, -P (O) ((C1-C6) alkyl) 2, -P (O) (aryl) 2, -SiMe3SF5 or -OH, where alkyl, alkylene, aryl, heteroaryl, and heterocyclyl are optionally substituted with one or more R9； or two R8 together when on adjacent carbons form an aryl ring optionally substituted with one or more R9； or two R8 together when on adjacent carbons form a heteroaryl ring optionally substituted with one or more R9； or two R8 together when on adjacent carbons form a heterocyclyl ring optionally substituted with one or more R9； each R9 is independently in each case selected from D, (C1-C6) alkyl, (C1-C6) alkoxy, (C3-C8) cycloalkyl, halogen, aryl, -OH, -CN, -C (O) R10, - C (O) NR10R11, -NR10C (O) R11, -NR10R11, -S (O) qR10, -S (O) qNR10R11, -NR10S (O) qR11, oxo, -P (O) ((C1-C6) alkyl) 2, -P (O) (aryl) 2, -SiMe3SF5 -O-aryl, CN, or -O-heteroaryl, wherein alkyl, aryl, and cycloalkyl are optionally substituted with one or more substituents independently selecte
