RAWSON, David James,STORER, Robert Ian,SWAIN, Nigel Alan
申请号：
ES12813989
公开号：
ES2593533T3
申请日:
2012.12.06
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula (I): ** Formula ** or a pharmaceutically acceptable salt thereof； in which X is -OCH2- or -CH2O-； Z is a group selected from naphthyl, phenyl and Het1, said group being optionally substituted independently with one to three substituents selected from Y1 and Y2； Y1 and Y2 are independently selected from F； Cl； CN； (C1-C8) alkyl, optionally substituted by (C3-C8) cycloalkyl and / or, if valence permits, by one to eight F； cycloalkyl (C3-C8), optionally substituted, if valence permits, by one to eight F； NR7R8； (C1-C8) alkyloxy, optionally substituted independently with one to three R9, and / or, if valence permits, by one to eight F； cycloalkyloxy (C3-C8), optionally substituted independently, if valence permits, by one to eight F and / or one to three R10 and, in addition, optionally condensed with a phenyl ring； phenyl, optionally independently substituted with one to three substituents selected from F and R10； phenoxy, optionally independently substituted with one to three substituents selected from F and R10； Het2； Het2-oxy； and Het3； R1a and R1b are independently H, (C1-C6) alkyl or cycloalkyl (C3-C6), optionally substituted, if valence permits, by one to eight F or, taken together with the N atom to which they are attached, they form a 3- to 8-membered monoheterocycloalkyl, said monoheterocycloalkyl being optionally substituted on a carbon atom of the ring by, if valence permits, from one to eight F； R2 R3 and R4 are independently H, F or -OCH3； R5 is H, CN, F, Cl, Het3 or R6； R6 is a group selected from (C1-C6) alkyl and (C1-C6) alkyloxy, in which each group is optionally substituted, if valence permits, by one to eight F； R7 and R8 are independently H； (C1-C8) alkyl, optionally independently substituted by one to three R11； cycloalkyl (C3-C8), optionally substituted by, if valence permits, from one to eight F and / or by one to three R10 and, in addition, optionally condensed with a phenyl ring； Het2 "bound to C"； or Het3 bound to C； R9 i
