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5-membered aromatic heterocyclic ring derivative that has NPY Y5 receptor antagonist activity
专利权人:
Ltd.;Shionogi & Co.
发明人:
HAYASHI, Kyohei,TAMURA, Yuusuke,OMORI, Naoki
申请号:
ES12777012
公开号:
ES2639940T3
申请日:
2012.04.25
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of formula (I): ** Formula ** or its pharmaceutically acceptable salt, wherein R1 is substituted or unsubstituted linear or branched C1-C10 alkyl, substituted or unsubstituted linear or branched C2-C10 alkenyl, C2 alkynyl -C10 linear or branched substituted or unsubstituted, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted C3-C8 cycloalkenyl or substituted amino, p is 1, and qyr are 0, a group of formula: ** Formula ** is a group of formula: ** Formula ** and R2 is substituted or unsubstituted linear or branched C1-C10 alkyl, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted C3-C8 cycloalkenyl, substituted or unsubstituted aryl, heteroaryl substituted or unsubstituted, or substituted or unsubstituted heterocyclyl, in which "substituted alkyl", "substituted alkenyl", "substituted alkynyl", "substituted cycloalkyl", "substituted cycloalkenyl", "substituted aryl", "substituted heteroaryl" or "substituted heterocyclyl" may be substituted in arbitrary position (positions) with one or more groups selected from halogen, hydroxy, mercapto, nitro, nitroso, cyano, azide, formyl, amino, carboxy, C1-C10 alkyl, C1-C10 haloalkyl, C2 alkenyl -C10, C2-C10 alkynyl, C3-C8 cycloalkyl, C3-C8 cycloalkenyl, aryl, heteroaryl, heterocyclyl, substituted carbamoyl, substituted sulfamoyl, substituted amidino, a group of formula: -O-R10, a group of formula: -OC (>; = O) -R10, a group of formula: -C (>; = O) -R10, a group of formula: -C (>; = O) -O-R10, a group of formula: -SR10 or a group of formula: -SO2-R10 (where R10 is C1-C10 alkyl, C1-C10 haloalkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C8 cycloalkyl, C3-C8 cycloalkenyl, aryl, heteroaryl, heterocyclyl, carbamoyl , sulfamoyl or amidino), and in which the term "aryl" refers to monocyclic or polycyclic aromatic carbocyclyl and monocyclic or polycyclic aromatic carbocyclyl condensed with one or two cyclic groups of 3 to 8 members, the term "heteroaryl" refers to a monocyclic o
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