Triazolopyrazine derivatives useful as anticancer agents

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专利权人:

PFIZER PRODUCTS INC.

发明人:

CHENG, HENGMIAO,CUI, JINGRONG JEAN,HOFFMAN, JACQUI ELIZABETH,JIA, LEI,JOHNSON, MARY CATHERINE,KANIA, ROBERT,LE, PHUONG THI QUY,NAMBU, MITCHELL,PAIRISH, MASON,SHEN, HONG,TRAN-DUBE, MICHELLE

申请号：

ES07734459

公开号：

ES2376913T3

申请日:

2007.04.30

申请国别(地区):

ES

年份:

2012

代理人:

摘要：

A compound of formula I: ** Formula ** in which: R1 and R2 are independently selected from hydrogen, Br, Cl, F, -O (CH2) nCH3, -NR10C (O) OR12, - (CR12R13) nNR10R11, -O (CH2) NOR10, - (CH2) NOR10, -C (O) R10, -C (O) OR10, -C (O) NR10R11, -NR10R11, -S (O) 2R10, -S (O) R10 , -S (O) 2NR10R11, -CF3, -CF2H, -NR10C (O) NR10R11, -NR10C (O) R11, -NR10S (O) 2R11, -N (CH2) n (C3-C8 cycloalkyl), -CN , - NO2, C1-C6 alkyl, C3-C8 cycloalkyl, 3- to 8-membered heteroalicyclyl, 3 to 8-membered heteroalicyclo- (3 to 8-membered heteroalicyclo), 8 to 10-membered heterobicyclic, 5 to 7-membered heteroaryl , C6-C10 aryl, C2-C6 alkenyl and C2-C6 alkynyl in which C1-C6 alkyl, C3-C8 cycloalkyl, 3 to 8 membered heteroalicyclo, 8 to 10 membered heterobicyclo, 5 to 7 membered heteroaryl, aryl C6-C10, C2-C6 alkenyl, and C2-C6 alkynyl are optionally substituted with one or more moieties selected from the group consisting of Br, Cl, F, - (CH2) nCH (OR10) CH3, - (CH2) nOR10, - (CH2) nC (CH3) 2OR10, -C (O) R10, - C (O) OR10, -C (R10R11) nC (O) OR10, -C (O) NR10R11, - (CR10R11) nC (O) NR10R11, - (CH2) nNR10R11, -S (O) 2R10, -S ( O) R10, -S (O) 2NR10R11, -CF3, -CF2H, - (CH2) nNR10C (O) NR10R11, - (CH2) nNR10C (O) OR11, -NR10C (O) R11, NR10C (O) OR11, -NR10S (O) 2R11, -CN, -NO2, oxo, C1-C6 alkyl, C3-C8 cycloalkyl, - (CH2) n (3- to 8-membered heteroalicyclo), - (CH2) n (5-7 heteroaryl members), - (CH2) n (C6-C10 aryl), C2-C6 alkenyl and C2-C6 alkynyl； R3 is a remainder of the formula: ** Formula ** in which R5, R6, R7, R8 and R9 are independently selected from hydrogen, Br, Cl, F, - (CH2) No10, -C (O) R10, - C (O) OR10, -C (O) NR10R11, -NR10R11, -S (O) 2R10, -S (O) R10, -S (O) 2NR10R11, -CF3, -CF2H, -NR10C (O) NR10R11, - NR10C (O) R11, -NR10SO2R11, -CN, -NO2, C1-C6 alkyl, C3-C8 cycloalkyl, 3 to 8 membered heteroalicyclo, 8 to 10 membered heterobicyclo, 5 to 7 membered heteroaryl, C6 aryl -C10, C2-C6 alkenyl and C2-C6 alkynyl, wherein C1-C6 alkyl, C3-C8 cycloalkyl, 3 to 8 membered heteroalicyclo, 8 to 1

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