POSS, Michael A.,TORTOLANI, David R.,DODD, Dharmpal S.,MUSSARI, Christopher P.,TOKARSKI, John S.,GAVAI, Ashvinikumar V.,ZHAO, Yufen,DELUCCA, George V.,O'MALLEY, Daniel,NORRIS, Derek J.,GILL, Patrice,Q
申请号：
ES14712815
公开号：
ES2669189T3
申请日:
2014.02.27
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of the formula ** Formula ** in which: A is ** Formula ** R is optionally substituted (C1-C6) alkyl, optionally substituted cycloalkyl (C3-C8) alkyl (C1-C6), aryl (C1-C6) alkyl -C6) optionally substituted, (C1-C6) alkyl -SO2- optionally substituted or (C1-C6) -OCO optionally ** Formula ** substituted； or Ris ** Formula ** wherein X and Y are independently selected from hydrogen, optionally substituted (C1-C6) alkyl, optionally substituted cycloalkyl (C3-C8), optionally substituted aryl, optionally substituted heteroaryl or optionally substituted heterocycle； Z is hydrogen, halogen, -OH, (C1-C6) alkyl, (C1-C6) alkoxy, -NR3R4, -CONR3R4, -OCONR3R4, -NR6OCOR3, -NR6CONR3R4, -NR6SO2NR3R4 5 or -NR6SO2R4； R1 is optionally substituted (C1-C6) alkyl, (C1-C6) -SO2- alkyl, optionally substituted, optionally substituted (C3-C8) cycloalkyl, (C3-C8) -SO2- optionally substituted cycloalkyl or heterocyclyl- CO optionally substituted； R2 is H, -CN, -COOH or -CONR7R8； R3 is hydrogen, optionally substituted (C1-C6) alkyl, optionally substituted cycloalkyl (C3-C8), optionally substituted alkenyl (C2-C6), optionally substituted alkynyl (C2-C6), cyanoalkyl (C1-C6), hydroxyalkyl (C1 -C6), optionally substituted aryl, optionally substituted arylalkyl (C1-C6), optionally substituted aryloxyalkyl (C1-C6) alkyl, (C1-C6) -SO2- alkyl, optionally substituted, optionally substituted heterocyclyl, optionally substituted heterocyclyl (C1-C6) alkyl substituted, optionally substituted heteroaryl or optionally substituted heteroarylalkyl (C1-C6), R4 is hydrogen, optionally substituted (C1-C6) alkyl or optionally substituted cycloalkyl (C3-C8)； or R3 and R4 can be taken together with the nitrogen atom to which they are attached to form an optionally substituted (C4-C8) heteroaryl or a heterocyclic (C4-C8) ring； R6 is hydrogen or optionally substituted (C1-C6) alkyl； R7 and R8 are independently hydrogen, optionally substituted (C1-C6) alkyl, optionally substituted cycloalkyl (C3-C8), optionall
