ARNELLE, Derrick,DEAVER, Daniel,DEAN, Reginald,TODTENKOPF, Mark
申请号：
ES09710456
公开号：
ES2671897T3
申请日:
2009.02.13
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of Formula V or VI: ** Formula ** or a pharmaceutically acceptable salt, or ester thereof, alone or in combination with a pharmaceutically acceptable carrier or excipient, where A1 is absent, is C1-C6 alkylene, substituted alkylene, C2-C6 alkenylene or C2-C6 alkynylene； A2 is hydrogen, NRbRc, (C>； = W) NRbRc, NRa (C>； = W) NRbRc, (C>； = W) OH, heteroaryl or substituted heteroaryl； n is 1, 2, 3 or 4； R3 is independently selected from the group consisting of: (i) hydrogen； (ii) aryl； substituted aryl； heteroaryl； substituted heteroaryl； (iii) substituted heterocyclic or heterocyclic； and (iv) -C1-C8 alkyl, C2-C8 alkenyl or C2-C8 alkynyl each containing 0, 1, 2 or 3 or more heteroatoms selected from O, S or N； substituted C1-C8 alkyl, substituted C2-C8 alkenyl or substituted C2-C8 alkynyl each containing 0, 1, 2 or 3 or more heteroatoms selected from O, S or N； C3-C12 cycloalkyl, or substituted C3-C12 cycloalkyl； C3-C12 cycloalkenyl or substituted C3-C12 cycloalkenyl； R30 is hydrogen, C3-C6 cycloalkyl, C3-C6 cycloalkenyl, heterocyclic or substituted heterocyclic； V1 is C>； = O, SO2, C1-C6 alkylene, substituted alkylene, C2-C6 alkenylene, C2-C6 alkynylene； V3 is absent, it is alkylene, substituted alkylene, C2-C6 alkenylene, C2-C6 alkynylene； heterocyclic, heteroaryl, aryl or C>； = O； V4 is absent, it is alkylene, substituted alkylene, C2-C6 alkenylene, C2-C6 alkynylene； heterocyclic, heteroaryl, aryl or C>； = O； W is O, S, NORa or NRa； Ra, Rb, Rc are each independently selected from: (i) hydrogen； (ii) aryl； substituted aryl； heteroaryl； substituted heteroaryl； (iii) substituted heterocyclic or heterocyclic； and (iv) -C1-C8 alkyl, -C2-C8 alkenyl or -C2-C8 alkynyl each containing 0, 1, 2 or 3 heteroatoms selected from O, S or N； substituted -C1-C8 alkyl, substituted C2-C8 alkenyl or substituted C2-C8 alkynyl each containing 0, 1, 2 or 3 heteroatoms selected from O, S or N； C3-C12 cycloalkyl, or substituted C3-C12 cycloalkyl； C3-C12 cycloalkenyl or
