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Pyrrole antifungal agents
专利权人:
F2G LIMITED
发明人:
SIBLEY, GRAHAM,DOWNHAM, ROBERT,PAYNE, LLOYD,LAW, DEREK,OLIVER, JASON,BIRCH, MIKE,DAVIES, GARETH
申请号:
ES09734928
公开号:
ES2535516T3
申请日:
2009.04.23
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A compound that is a pyrrole derivative of formula (I), or a pharmaceutically acceptable salt thereof, for use in the prevention or treatment of a fungal disease: ** Formula ** where: R1 represents hydrogen, C1-C8 alkyl , C2-C8 alkenyl, C2-C8 alkynyl, -COR 'or -SO2 (C1-C4 alkyl) unsubstituted or substituted, or a group -A2, -L2-A2, -L3-A2, -A2-L3- A3 or -A4; A1 represents a bond or a phenyl, naphthyl, 5- or 6-membered heterocyclyl group or 8-membered unsubstituted or substituted heterocyclyl group; A2 and A3 are the same or different and represent C3-C6 cycloalkyl or a C6-C10 aryl or 5- to 12-membered heterocyclyl group; A4 is a 5- to 12-membered unsubstituted or substituted heterocyclyl group in which 1 or 2 carbon atoms of the ring are substituted with a group selected from>; C (>; = O),>; S (>; = O) 2,>; C (>; = NOR7) in which R7 is hydrogen or a C1-C4 alkyl group,>; C>; = CH2 or>; C (-OCH2CH2O-); L1 represents a bond, a C1-C6 alkylene group in which none, one or two -CH2- groups are independently substituted with -O- or -NR'-, or a 5- to 7-membered heterocyclyl group in which R ' it is hydrogen, unsubstituted C1-C4 alkyl or C1-C4 alkyl substituted with an unsubstituted C1-C4 alkoxy group; L2 represents -NR'-, -O-, -CO-, -OCO-, -OCONR'R "-, -CONR'R" - or -SO2-, in which R 'and R "independently represent hydrogen, alkyl C1-C8, C2-C8 alkenyl or C2-C8 alkynyl; L3 represents a bond or a C1-C4 alkylene group in which none, one or two -CH2 groups are independently substituted with -O-, -S- or - NR'-, wherein R 'represents hydrogen, C1-C8 alkyl, C2-C8 alkenyl or C2-C8 alkynyl; n is 1; R6 represents hydrogen or C1-C4 alkyl; R5 represents an unsubstituted or substituted group selected from C6-C10 aryl, a 5-12 membered heterocyclyl group, C1-C8 alkyl and C3-C6 cycloalkyl, hydrogen, halogen or a group of formula -B1-B2 or -B3; B1 represents an unsubstituted C6-C10 aryl group or substituted; B2 represents a C6-C10 aryl or 5- to 12-membered unsubstituted or
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