SIBLEY, GRAHAM EDWARD MORRIS,DOWNHAM, ROBERT,PAYNE, LLOYD JAMES,LAW, DEREK,OLIVER, JASON DAVID,BIRCH, MIKE,DAVIES, GARETH MORSE
申请号：
ES13167337
公开号：
ES2526083T3
申请日:
2009.04.23
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound that is a pyrrole derivative of formula (I), or a pharmaceutically acceptable salt thereof, for use in the prevention or treatment of a fungal disease: ** Formula ** in which: R1 represents hydrogen, C1 alkyl -C8, C2-C8 alkenyl, C2-10 C8 alkynyl, -COR 'or -SO2 (C1-C4 alkyl) unsubstituted or substituted, or a group -A2, -L2-A2, -L3-A2, -A2- L3-A3 or -A4； A1 represents a bond or a phenyl, naphthyl, 5- to 6-membered heterocyclyl group or 8-to-unsubstituted or substituted heterocyclyl group； A2 and A3 are the same or different and represent C3-C6 cycloalkyl or a C6-C10 aryl or 5- to 12-membered heterocyclyl group； A4 is an unsubstituted or substituted 5 to 12 membered heterocyclyl group in which 1 or 2 ring carbon atoms are substituted with a group selected from>； C (>； = O),>； S (>； = O) 2,>； C (>； = NOR7) in which R7 is hydrogen or a C1-C4 alkyl group,>； C>； = CH2 or>； C (-OCH2CH2O-)； L1 represents a bond, a C1-C6 alkylene group in which none, one or two -CH2- groups are independently substituted with -O- or -NR'-, or a 5- to 7-membered heterocyclyl group in which R ' it is hydrogen, unsubstituted C1-C4 alkyl or C1-C4 alkyl substituted with an unsubstituted C1-C4 alkoxy group； L2 represents -NR'-, -O-, -CO-, -OCO-, -OCONR'R "-, -CONR'R" - or -SO2-； L3 represents a bond or a C1-C4 alkylene group in which none, one or two -CH2- groups are independently substituted with -O-, -S- or -NR'-； n is 1； R6 represents hydrogen or C1-C4 alkyl； R5 represents an unsubstituted or substituted group selected from C6-C10 aryl, a 5-12 membered heterocyclyl group, C1-C8 alkyl and C3-C6 cycloalkyl, hydrogen, halogen or a group of formula -B1-B2 or -B3； B1 represents an unsubstituted or substituted C6-C10 aryl group； B2 represents a C6-C10 aryl or 5- to 12-membered heterocyclyl group unsubstituted or substituted； B3 is an unsubstituted or substituted 5 to 12 membered heterocyclyl group in which 1 or 2 ring carbon atoms are substituted with a group selected from
