CHANTIGNY, YVES ANDRE,KLEINMAN, EDWARD FOX,ROBINSON, JR.
申请号：
ES03740911
公开号：
ES2518940T3
申请日:
2003.06.25
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound of formula ** Formula ** in which A is of formula ** Formula ** X and Y are each independently hydrogen, fluorine, chlorine, bromine or (C1-C6) alkyl； R1 is (C2-C6) alkyl, (C3-C6) alkenyl or optionally substituted benzyl； wherein said benzyl may be optionally substituted with one to three substituents independently selected from HO-, (C1-C6) -O- alkyl, halo and amino； R2 is (C1-C6) alkyl, (C2-C6) alkenyl, (C3-C6) alkynyl, (C3-C10) cycloalkyl, (C6-C10) aryl, (C1-C9) heterocyclyl, (C1-C9) heteroaryl , aryl (C6-C10) alkyl (C1-C4), heterocyclyl (C1-C9) alkyl (C1-C4), heteroaryl (C1-C9) -alkyl- (C1-C4) or cycloalkyl (C3-C10) -alkyl (C1-C4), in which each of the aforementioned groups may be optionally substituted with one to three substituents independently selected from halo, (C1-C6) alkyl, (C1-C6) alkoxy or -CF3； R3 is hydrogen, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, (C3-C10) cycloalkyl, (C1-C9) heterocyclyl, (C1-C9) heteroaryl or (C6-) aryl C10)； wherein each of the aforementioned groups may be optionally substituted with one to three substituents independently selected from HO-, (C1-C6) -O- alkyl, halo and amino； R4 is HO- or R1420 R15N-； R6 is a radical selected from the group consisting of hydrogen, halo, (C1-C6) alkyl, (C2-C6) alkenyl, (C3-C6) alkynyl, (C3-C10) cycloalkyl, aryl (C6-C10) -, heteroaryl (C1-C9) -, heterocyclic (C1-C9) -, -OH, (C1-C6) alkyl - O-, cycloalkyl (C3-C10) -O-, aryl (C6-C10) -O-, heteroaryl (C1-C9) -O-, heterocyclic (C1-C9) -O-, cycloalkyl (C3-C10) -alkyl (C1-C6) -O-, aryl (C6-C10) -alkyl (C1-C6) - O-, heteroaryl (C1-C9) -alkyl (C1-C6) -O-, heterocyclic (C1-C9) -alkyl (C1-C6) -O-, R16R17N- (C>； = O) -, R16- ( C>； = O) - (R25-N) -, R16R17-N-SO2-, R18-SO2-, R16-SO2- (NR19) -, R18-SO3-, -CN, R1825 - (C>； = O) -O-, R18- (C>； = O) -, R16R17N- (C>； = O) -O-, R16R17N- (C>； = O) - (R25-N) -, R19-O- (C>； = O) - (R25-N) -, and R19-O- (C>； = O) -； wherein each of said moieties of (C1-C6) alkyl, cycloalkyl (C3-C10), a
