KELLY, MICHAEL J.,LAYTON, MARK E.,LIQUORI, MICHAEL E.,OGINO, YOSHIO,ONOZAKI, YU,SANDERSON, PHILIP E.,WANG, JIABING
申请号：
ES07862428
公开号：
ES2527567T3
申请日:
2007.12.03
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound according to Formula A: ** Formula ** where: E, F, G, H, I, J, K, L and M are independently selected from: C or N, where each E, F, G, H, I, J, K, L and M are optionally substituted with R1； a is 0 or 1； b is 0 or 1； m is 0, 1 or 2； p is independently 0, 1,2, 3, 4 or 5； The Y ring is cycloalkyl (C4-C7), said cycloalkyl is optionally substituted with one or more substituents selected from: (C1-C6) alkyl, (C1-C6) alkoxy, CO2H, halo, CN, OH and NH2； The Z ring is selected from: (C3-C8) cycloalkyl, aryl, heteroaryl and heterocyclyl； R1 is selected from: H, oxo, (C>； = O) aOb (C1-C) alkyl 10, aryl (C>； = O) aOb, (C>； = O) aOb alkenyl (C2-C10), (C>； = O) aOb alkynyl (C2-C10), CO2H, halo, OH, Ob perfluoroalkyl (Cr-C6), (C>； = O) aNR7R8, CN, (C>； = O) aOb cycloalkyl (C3-C8), S (O) mNR7R815, SH, S (O) m-(C1-C10) alkyl and (C>； = O) aOb-heterocyclyl, said alkyl, aryl, alkenyl, alkynyl, cycloalkyl and heterocycle are optionally substituted with one or more substituents selected from R6； R2 is independently selected from: oxo, (C>； = O) aOb (C1-C10) alkyl, aryl (C>； = O) aOb, (C>； = O) aOb alkenyl (C2-C10), (C>； = O ) aOb alkynyl (C2-C10), CO2H, halo, OH, Ob perfluoroalkyl (Cr-C6), (C>； = O) aNR7R8, CN, (C>； = O) aOb cycloalkyl (C3-C8), SH, S (O) mNR7R8, S (O) m-(C1-C10) alkyl and (C>； = O) aOb-heterocyclyl, said alkyl, aryl, alkenyl, alkynyl, cycloalkyl and heterocycle are optionally substituted with one or more substituents selected from R6； R6 is: (C>； = O) aOb C1-C10 alkyl, aryl (C>； = O) aOb, C2-C10 alkenyl, C2-C10 alkynyl, heterocyclyl (C>； = O) aOb, CO2H, halo, CN, OH , perfluoroalkyl ObC1-C6, Oa (C>； = O) bNR7R8, oxo, CHO, (N>； = O) R7R8, S (O) mNR7R8, SH, S (O) m-alkyl (C1-C10) or (C >； = O) aOb C3-C8 cycloalkyl, said alkyl, aryl, alkenyl, alkynyl, heterocyclyl and cycloalkyl optionally substituted with one or more substituents selected from R6a； R6a is selected from: (C>； = O) aOb (C1-C) alkyl 10, Oa perfluoroalkyl
