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アルテミシニン及びその誘導体を使用する良性色素性ホクロ(母斑)の処置及び予防
专利权人:
エピフアルマ・アクチエンゲゼルシヤフト
发明人:
シフト・カーター,ロゼマリー
申请号:
JP2008535868
公开号:
JP5119155B2
申请日:
2006.10.19
申请国别(地区):
JP
年份:
2013
代理人:
摘要:
< Conversion 1 > As for benign pigment characteristic hokuro or athletes foot of the foot or tamushi of the nail formula (i) [in formula, as for X to display CO, CHOZ or CHNRZ, as for Z hydrogen, line or ramification (C1 C6) alkyl, line or ramification (C2 C6) arukeniru, line or ramification (C2 C6) arukiniru, (C3 C8) shikuroarukiru, (C6 C24) aryl, (C7 C24) aralkyl, m and p CH2 (C6 H4) COOM and COR3, CSR3, C (NR6) R3, SOR4, SO2 OM and SO2 NR7R8, SO2 O arutemishiniru and SO2 NH arutemishiniru, POR from4 R5 and PSR4 R5 it is selected, as for R3 line or ramification (C1 C6) alkyl, line or ramification (C1 C6) the alkoxy, line or ramification (C2 C6) arukeniru, line or ramification (C2 C6) arukiniru, (C3 C8) shikuroarukiru, (C6 C24) aryl, (C6 C10) the aryl oxy, (C7 C24) the aralkyl, - (CH2) n COOM (as for n displays natural number 1 - 6 here) or 10 To display ji - hidoroarutemishiniru, R4 and R5 to be selected becoming independent, line or ramification (C1 C6) alkyl, line or ramification (C2 C6) arukeniru, line or ramification (C2 C6) arukiniru, (C3 C8) shikuroarukiru, (C6 C24) aryl, (C7 C24) aralkyl, OM, line or ramification (C1 C6) the alkoxy, (C6 C10) from aryl oxy and NR7 R8, as for R6 line or ramification (C1 C6) alkyl, line or ramification (C2 C6) arukeniru, line or ramification(C2 C6) arukiniru, (C3 C8) shikuroarukiru, (C6 C24) it is selected aryl and (C7 C24) from the aralkyl, M hydrogen or it displays the cation which the medicine manufacture study can be allowed, and, R7 and R8 becoming independent, hydrogen or line or ramification (C1 C6) displays alkyl or or, R7 and R8 becomes simultaneous and the alkylene bridge (C4 C6) forms, and R is selected from the basis which is quoted vis-a-vis hydrogen and R6], in section one for the applicable, especially section compoundIt can deal with the active ingredient which is done. In addition as for the said chemical compound, it is effective to also the prevention of the acquired charact
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