FREYNE, EDDY JEAN EDGARD,法艾格,法艾格,PERERA, TIMOTHY PIETRO SUREN,皮苏伦,皮蘇倫,BUIJNSTERS, PETER JACOBUS JOHANNES ANTONIUS,布安东,布安東,WILLEMS, MARC,威马克,威馬克,DIELS, GASTON STANISLAS MARCELLA,戴马瑟,戴馬瑟,EMBRECHTS, WERN
申请号：
TW093114851
公开号：
TWI379835B
申请日:
2004.05.26
申请国别(地区):
TW
年份:
2012
代理人:
摘要：
This Hair Ming Department Off what following formula: compounds:(I)Its N- oxide forms, Medical Drug is subjected to Jia Cheng Which Class Ji Li Body Iso Agencies object forms, whereinZ represents NHY representative-C3-9 alkyl-,- C2-9 alkenyls-,- C3-7 alkyl-CO-NH,Visual Qing Condition with amido,Single-or two(C1-4 alkyl)Amido or C1-4 Alkoxycarbonylaminos-substitution,- C3-7 alkenyls-CO-NH-,Visual Qing Condition with amido,Single-or two(C1-4 alkyl)Amido-or C1-4 Alkoxycarbonylaminos-substitution,C1-5 alkyl-NR13-C1-5 alkyl-,C1-5 alkyl-NR14-CO-C1-5 alkyl-,C1-6 alkyl-CO-NH-,- C1-5 alkyl-CONR15-C1-5 alkyl-,C1-3 alkyl-NH-CO-Het20-,- C1-2 alkyl-CO-Het21-CO-,- C1-2 alkyl-NH-CO-CR16R17-NH-,- C1-2 alkyl-CO-NH-CR18R19-CO-,- C1-2 alkyl-CO-NR20-C1-3 alkyl-CO-,Or-NR22-CO-C1-3 alkyl-NH-X1 represents Ge Zhi Jie Key Knot, O or-O-C1-2 alkyl-X2 represents Ge Zhi Jie Key Knot ,-CO-C1-2 alkyl-, NR12 ,-NR12-C1-2 alkyl ,-O-N=CH- or-C1-2 alkyl-Each Independence of R1 and R2 are vertical to represent Hydrogen Huo Halogen basesR3 represents HydrogenR4 represents Hydrogen or C1-4 alkoxiesEach Independence of R12 and R13 are vertical to represent Hydrogen or C1-4 alkylR14 and R15 represent HydrogenEach Independence of R16 and R17 are vertical to represent Hydrogen or C1-4 alkylEach Independence of R18 and R19 are vertical to represent Hydrogen or C1-4 alkyl, is replaced with Ben Ji Huo Hydroxyalkyl bases to Visual Qing ConditionEach Independence of R20 and R21 are vertical to represent Hydrogen or C1-4 alkyl, is replaced with C1-4 alkoxies to Visual Qing ConditionEach Independence of Het20, Het21 and Het22 is vertical represent the free pyrroless piperidinyls of a Ge Election, 2- Pyrrolizidines anilide or piperidyl institute Agencies at group Miscellaneous Ring, Visual feelings Condition with the substitution of Hydroxyalkyl bases.本發明係關於下式化合物:(I)其N-氧化物形式、醫藥可接受加成鹽類及立體異構物形式,其中Z 代表NH;Y 代表-C3-9烷基-、-C2-9烯基-、-C3-7烷基-CO-NH、視情況地以胺基、單-或二(C1-4烷基)胺基或C1-4烷氧基羰基胺基-取代,-C3-7烯基-CO-NH-,視情況地以胺基、單-或二(C1-4烷基)胺基-或C1-
