BONDY, Steven S.,CANNIZZARO, Carina E.,CHOU, Chien-hung,HALCOMB, Randall L.,HU, Yunfeng Eric,LINK, John O.,LIU, Qi,SCHROEDER, Scott D.,TSE, Winston C.,ZHANG, Jennifer R.,BONDY STEVEN S,BONDY, STEVEN S.,CANNIZZARO CARINA E,CANNIZZARO, CARINA E.,CHOU CHIEN-HUNG,CHOU, CHIEN-HUNG,HALCOMB RANDALL L,HALCOMB, RANDALL L.,HU YUNFENG ERIC,LINK JOHN O,LINK, JOHN
申请号：
ES12738307
公开号：
ES2553449T3
申请日:
2012.07.05
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula I: ** Formula ** in which: A is a 6-membered heteroaryl comprising one or two nitrogens, wherein the 6-membered heteroaryl is substituted with a group Z1 and optionally substituted with one or more groups Z2； B is absent； or B is -O- and the nitrogen to which the group -O- is attached is N +； W is -CR3aR3b-, -O-, -10 NR4- or -OCR3aR3b-； R1 is aryl, heteroaryl or heterocycle, wherein any aryl, heteroaryl or heterocycle of R1 is optionally substituted with one or more Z3 groups； R2 is a 6 membered aryl, 5 membered heteroaryl or 6 membered heteroaryl, wherein any 6 membered aryl, 5 membered heteroaryl or 6 membered heteroaryl of R2 is optionally substituted with one or more Z4 groups； each R3a and R3b is independently selected from H, halogen, (C1-C6) alkyl, carbocycle (C3-C7), haloalkyl (C1-C3), heteroalkyl (C1-C6), heteroaryl-alkyl (C1-C6), heterocyclyl -C1-C6 alkyl, -NRaRb, and -NRcCORd, wherein any (C1-C6) alkyl of R3a and R3b is optionally substituted with one or more OH groups； or R3a and R3b together with the carbon atom to which they are attached form a carbocycle (C3-C6)； R4 is selected from H, (C1-C6) alkyl, (C3-C6) carbocycle, aryl (C1-C6) alkyl and heteroaryl (C1-C6) alkyl； Ra and Rb are each independently selected from H, (C1-C8) alkyl, (C2-C8) alkenyl, (C2-C8) alkynyl, carbocycle (C3-C7), heterocycle, heteroaryl, aryl, haloaryl, haloheteroaryl, haloheterocycle , halo (C1-C8) alkyl and (C1-C8) heteroalkyl, or Ra and Rb together with the nitrogen to which they are attached form a 5, 6 or 7 membered heterocycle； each Rc is independently selected from H, (C1-C8) alkyl, (C2-C8) alkenyl, (C2-C8) alkynyl, carbocycle (C3-C7), heterocycle, heteroaryl, aryl, haloaryl, haloheteroaryl, haloheterocycle, haloalkyl ( C1-C8) and heteroalkyl (C1-C8)； each Rd is independently selected from (C1-C8) alkyl, (C2-C8) alkenyl, (C2-C8) alkynyl, carbocycle (C3-C7), heterocycle, heteroaryl, aryl, haloaryl, haloheteroaryl, haloheterocycle, haloalkyl (C1- C8) an
