BLANCO-PILLADO, MARIA-JESUS,COHEN, MICHAEL PHILIP,FILLA, SANDRA ANN,HUDZIAK, KEVIN JOHN,KOHLMAN, DANIEL TIMOTHY,BENESH, DANA RAE,VICTOR, FRANTZ,XU, YAO-CHANG,YING, BAI-PING,ZACHERL, DEANNA PIATT,ZHANG
申请号：
CA2537936
公开号：
CA2537936C
申请日:
2004.09.03
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
ABSTRACT The present invention relates to compounds of formula I: (I) or apharmaceutically acceptable acid addition salt thereof, where； X is C(R3c= orN=； R1 is C2-C6 alkyl, substituted C2-C6 alkyl, C3-C7 cycloalkyl, substitutedC3-C7 cycloalkyl, phenyl, substituted phenyl, heterocycle, or substitutedheterocycle； R2 is hydrogen, C1-C3 n-alkyl, C3-C6 cycloalkyl-C1-C3 alkyl, or agroup of formula II (II) provided that when R1 is C2-C6 alkyl or substitutedC2-C6 alkyl, R2 is hydrogen or methyl； R3a, R3b, and, when X is C(R3c)=, R3c,are each independently hydrogen, fluoro, or methyl, provided that no more thanone of R3a, R3b, and R3c may be other than hydrogen； R4 is hydrogen or C1-C3alkyl； R5 is hydrogen, C1-C3 alkyl, or C3-C6 cycloalkylcarbonyl, provided thatwhen R3a is other than hydrogen, R5 is hydrogen； R6 is hydrogen or C1-C6alkyl； and n is an integer from 1 to 6 inclusively. The compounds of thepresent invention are useful for activating 5-HT1F receptors, inhibitingneuronal protein extravasation, and for the treatment or prevention ofmigraine in a mammal.
