BABAOGLU, Kerim,BRIZGYS, Gediminas,CHA, Jake,CHEN, Xiaowu,GUO, Hongyan,HALCOMB, Randall L.,HAN, Xiaochun,HUANG, Richard,LIU, Hongtao,MCFADDEN, Ryan,MITCHELL, Michael L.,QI, Yingmei,ROETHLE, Paul A.,XU
申请号：
ES15202564
公开号：
ES2668422T3
申请日:
2013.04.19
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of formula I ': ** Formula ** A is phenyl, pyridinyl, pyrimidinyl, pyrazinyl, pyridinyl-2 (1 H) -one, tetrahydropyrimidin-2 (1 H) -one, imidazolidinyl-2-one, pyrrolidinyl-2- one, pyrrolidinyl, pyridazinyl, thiazolyl, pyrazine-2 (1 H) -one, piperazinyl-2-one, piperazinyl, imidazolyl, morpholinyl, 1,2,3,6-tetrahydropyridinyl or piperidinyl, wherein any phenyl, pyridinyl, pyrimidinyl, pyrazinyl, pyridinyl-2 (1H) -one, tetrahydropyrimidine-2 (1H) -one, imidazolidinyl-2-one, pyrrolidinyl-2-one, pyrrolidinyl, pyridazinyl, thiazolyl, pyrazin-2 (1H) -one, piperazinyl-2 -one, piperazinyl, imidazolyl, morpholinyl, 1,2, 3,6-tetrahydropyridinyl or piperidinyl of A is optionally substituted with one to five groups Z1a, and B is aryl, heteroaryl or heterocycle, wherein any aryl, heteroaryl or heterocycle of B is optionally substituted with one to five groups Z1b； or A and B together form a bicyclic aryl, bicyclic heteroaryl or bicyclic heterocycle (C9-C14), wherein the bicyclic aryl, bicyclic heteroaryl or bicyclic heterocycle (C9-C14) is optionally substituted with one to five Z1b groups； each Z1a is independently selected from halo, (C1-C3) alkyl, (C2-C3) alkenyl, (C2-C3) alkynyl, (C1-C3) haloalkyl, (C3-C7) carbocycle, heterocycle, -O (C1) alkyl -C3), alkenyl -O (C2-C3), alkynyl -O (C2-C3), -NRcRd, -NRaC (O) Ra, -C (O) ORb and -C (O) NRcRd, where any carbocycle and (C3-C7) heterocycle of Z1a is optionally substituted with one to five halogen or (C1-C6) alkyl groups； each Z1b is independently selected from halo, CN, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, (C1-C6) haloalkyl, (C3-C7) carbocycle, heteroaryl, heterocycle, alkyl aryl (C1-C6) -, -OH, alkyl -O (C1-C6), alkenyl -O (C2-C6), alkynyl -O (C2-6), -NRcRd, -NRaC (O) R a, - C (O) ORb and -C (O) NRcRd, wherein any Z1b carbocycle and heterocycle (C3-C7) is optionally substituted with one to five halogen or (C1-C6) alkyl groups； and Ra, Rb, Rc and Rd are each independently H or (C1-C6) alkyl； wherein ada hetero
