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Fatty acid fumarate derivatives and their uses
专利权人:
Inc.;Catabasis Pharmaceuticals
发明人:
VU, Chi,BEMIS, Jean,JIROUSEK, Michael,MILNE, Jill,SMITH, Jesse
申请号:
ES11732212
公开号:
ES2637266T3
申请日:
2011.01.07
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of Formula IA, IB or IC: ** Formula ** or a pharmaceutically acceptable salt, hydrate, solvate, enantiomer or stereoisomer thereof; wherein each W1 and W2 is independently nothing, O, S, NH or NR or W1 and W2 can be taken together to form an optionally substituted imidazolidine or piperazine group; each a, b, c and d is independently -H, -D, - CH3, -OCH3, -OCH2CH3, -C (O) OR or benzyl or two between a, b, c and d can be taken together, together with the only carbon at which are attached, to form a cycloalkyl or a heterocycle; each n, o, p and q is independently 0, 1 or 2; each L is independently nothing, -O-, -C (O) -, -S-, -S (O) -, -S (O) 2-, -SS-, - (C1-C6 alkyl) -, - (C3-C6 cycloalkyl) -, a heterocycle, a heteroaryl, ** Formula ** in which the representation of L is not directionally limited to either left or right as represented, but the left side or the right side of L may be attached to the W1 side of the compound of Formula IA, IB or IC; each R6 is independently -H, -D, C1-C4 alkyl, halogen, cyano, oxo, thiooxo, -OH, -C (O) C1-C4 alkyl, -O aryl, -O-benzyl, -OC (O) C1-C4 alkyl, C2-C3 alkene, C2-C3 alkyne, -NH2, -NH (C1-C3 alkyl), -N (C1-C3 alkyl) 2, -NH (C (O) C1-C3 alkyl), -N (C (O) C1-C3 alkyl) 2, -SH, -S (C1-C3 alkyl), -S (O) C1-C3 alkyl, -S (O) 2 C1-C3 alkyl; each g is independently 2, 3 or 4; each h is independently 1, 2, 3 or 4; each m is independently 0, 1, 2 or 3; if m is more than 1, then L can be the same or different; each m1 is independently 0, 1, 2 or 3; k is 0, 1, 2 or 3; z is 1.2 or 3; each R4 is independently H or optionally substituted C1-C6 alkyl, wherein the methylene unit of the C1-C6 alkyl may optionally be substituted by any between O or NR and, in NR4R4, both R4 when taken together with the nitrogen to which they are together they can form a heterocyclic ring selected from the group consisting of pyrrolidine, piperidine, morpholine, piperazine or pyrrole; each R3 is independently H or C1-C6 alkyl; each R5 is independently e,
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