A compound of Formula IA, IB or IC: ** Formula ** or a pharmaceutically acceptable salt, hydrate, solvate, enantiomer or stereoisomer thereof； wherein each W1 and W2 is independently nothing, O, S, NH or NR or W1 and W2 can be taken together to form an optionally substituted imidazolidine or piperazine group； each a, b, c and d is independently -H, -D, - CH3, -OCH3, -OCH2CH3, -C (O) OR or benzyl or two between a, b, c and d can be taken together, together with the only carbon at which are attached, to form a cycloalkyl or a heterocycle； each n, o, p and q is independently 0, 1 or 2； each L is independently nothing, -O-, -C (O) -, -S-, -S (O) -, -S (O) 2-, -SS-, - (C1-C6 alkyl) -, - (C3-C6 cycloalkyl) -, a heterocycle, a heteroaryl, ** Formula ** in which the representation of L is not directionally limited to either left or right as represented, but the left side or the right side of L may be attached to the W1 side of the compound of Formula IA, IB or IC； each R6 is independently -H, -D, C1-C4 alkyl, halogen, cyano, oxo, thiooxo, -OH, -C (O) C1-C4 alkyl, -O aryl, -O-benzyl, -OC (O) C1-C4 alkyl, C2-C3 alkene, C2-C3 alkyne, -NH2, -NH (C1-C3 alkyl), -N (C1-C3 alkyl) 2, -NH (C (O) C1-C3 alkyl), -N (C (O) C1-C3 alkyl) 2, -SH, -S (C1-C3 alkyl), -S (O) C1-C3 alkyl, -S (O) 2 C1-C3 alkyl； each g is independently 2, 3 or 4； each h is independently 1, 2, 3 or 4； each m is independently 0, 1, 2 or 3； if m is more than 1, then L can be the same or different； each m1 is independently 0, 1, 2 or 3； k is 0, 1, 2 or 3； z is 1.2 or 3； each R4 is independently H or optionally substituted C1-C6 alkyl, wherein the methylene unit of the C1-C6 alkyl may optionally be substituted by any between O or NR and, in NR4R4, both R4 when taken together with the nitrogen to which they are together they can form a heterocyclic ring selected from the group consisting of pyrrolidine, piperidine, morpholine, piperazine or pyrrole； each R3 is independently H or C1-C6 alkyl； each R5 is independently e,
