A compound of formula I: ** Formula ** or a salt, hydrate or solvate thereof； wherein: R1 is arylalkyl or heteroarylalkyl, each optionally substituted with 1-4 independent Z1； R3 is hydrogen, hydroxy, alkoxy or alkylamino； R6 is optionally substituted aryl, substituted heteroaryl, or partially unsaturated heterocyclyl, wherein R6 is optionally substituted by 1-3 groups, independently selected from alkyl, cycloalkyl, heterocyclyl, alkoxy, hydroxyalkyl, -C (O) NR7R8, and Z1； each of which may also be optionally substituted； R7 and R8 are each independently selected from H, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heterocyclyl, heteroaryl, or R7 and R8 together with the nitrogen form a heterocyclyl or heteroaryl； Each Z1 is halogen, CN, NO2, OR15, SR15, S (O) 2OR15, NR15R16, perfluoroalkyl C1-C2, perfluoroalkoxy C1-C2, 1,2-methylenedioxy, C (O) OR15, C (O) NR15R16, OC (O) NR15R16, NR15C (O) NR15R16, C (NR16) NR15R16, NR15C (NR16) NR15R16, S (O) 2NR15R16, R17, C (O) R17, NR15C (O) R17, S (O) R17, S (O) 2R17, R16, oxo, C (O) R16, C (O) (CH2) nOH, (CH2) nOR15, (CH2) nC (O) NR15R16, NR15S (O) 2R17, where n is independently 0- 6 inclusive； each R15 is independently hydrogen, C1-C4 alkyl or C3-C6 cycloalkyl； each R16 is independently hydrogen, alkenyl, alkynyl, C3-C6 cycloalkyl, aryl, heterocyclyl, heteroaryl, C1-C4 alkyl or C1-C4 alkyl substituted with C3-C6 cycloalkyl, aryl, heterocyclyl or heteroaryl； and each R17 is independently C3-C6 cycloalkyl, aryl, heterocyclyl, heteroaryl, C1-C4 alkyl or C1-C4 alkyl substituted with C3-C6 cycloalkyl, aryl, heterocyclyl or heteroaryl.Un compuesto de fórmula I:**Fórmula** o una sal, hidrato o solvato del mismo； en donde: R1 es arilalquilo o heteroarilalquilo, cada uno opcionalmente sustituido con 1-4 Z1 independientes； R3 es hidrógeno, hidroxilo, alcoxi o alquilamino； R6 es arilo opcionalmente sustituido, heteroarilo sustituido, o heterociclilo parcialmente insaturado, en donde R6 está opcionalmente sustituido por 1-3 grupos, selec
