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メタ位に置換基を有する芳香族六員環誘導体
专利权人:
DAIICHI SANKYO CO LTD
发明人:
NAGAMOCHI MASATOSHI,永持 雅敏,GOTANDA TAKENORI,五反田 建徳,GOTO YASUHARU,後藤 泰治,SASAKI JUNKO,佐々木 潤子,YOSHINO TOSHIJI,吉野 利治,ISOBE TAKASHI,磯部 崇
申请号:
JP2015002786
公开号:
JP2016128387A
申请日:
2015.01.09
申请国别(地区):
JP
年份:
2016
代理人:
摘要:
PROBLEM TO BE SOLVED: To provide a compound having excellent inhibitory activity against a retinoic acid receptor-related orphan receptor γt.SOLUTION: Provided is a compound represented by a formula (I) or a pharmacologically acceptable salt thereof. [R1 is a C3 to C6 cycloalkyl group or a phenyl group which may be substituted with 1 to 4 substituents selected from a substituent group A R2 is H, a C2 to C7 carboxyalkyl group, OH, or the like a formula -U-T- represents a formula -CH2-CH2- or a formula -CH=CH- R3 and R4 each independently represents H, a halogen, or a C1 to C6 alkyl group Y represents a methylene group or O R5 represents a phenyl group, a pyridyl group, or the like which may be substituted with 1 to 4 substituents selected from a substituent group B Q1 is N or a formula =C(R6)- Q2 is N or a formula =C(R7)- R6 and R7 are each independently H, a halogen, or the like the substituent group A includes C1 to C6 alkyl sulfonyl groups or the like and the substituent group B includes a halogen, C1 to C6 alkyl groups, a hydroxyl group, or the like.]SELECTED DRAWING: NoneCOPYRIGHT: (C)2016,JPO&INPIT【課題】優れたレチノイン酸受容体関連オーファン受容体γt阻害作用を有する化合物の提供。【解決手段】式(I)で表される化合物又はその薬理上許容される塩。[R1は置換基群Aで1~4個置換されていてもよいC3-C6シクロアルキル基又はフェニル基;R2はH、C2-C7カルボキシアルキル基、OH等;式-U-T-は式-CH2-CH2-又は式-CH=CH-;R3及びR4は各々独立にH、ハロゲン又はC1-C6アルキル基;Yはメチレン基又はO;R5は置換基群Bで1~4個置換されていてもよいフェニル基、ピリジル基等;Q1はN又は式=C(R6)-;Q2はN又は式=C(R7)-;R6及びR7は各々独立にH、ハロゲン等;置換基群AはC1-C6アルキルスルホニル基等;置換基群Bはハロゲン、C1-C6アルキル基、水酸基等]【選択図】なし
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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